Accurel MP 1000 as a support for the immobilization of lipase from Burkholderia cepacia: Application to the kinetic resolution of myo-inositol derivatives

- Lipase PS has been immobilized on Accurel in less than 1 h with a 70% increase in activity.
- Irreversible inhibition with D-pNPP suggested the involvement of the open form of the lipase in the immobilization process.
- The new biocatalyst is much more active that the commercial one in hydrolysis and synthetic reactions.
- The resolution of (±)-1,3,4-tri-O-benzyl-myo-inositol (1) has been optimized using RSM.
- The new biocatalyst is more efficient in kinetic resolution of 1 than Novozym 435.