Effects of high hydrostatic pressure treatment on allergenicity and structural properties of soybean protein isolate for infant formula

► HHP treatment could reduce allergenicity of SPI for infant formula. ► The determinants of soy allergens were complexes in current study. ► HHP could alter allergen interactions such as free SH content and hydrophobicity. ► HHP could interfere with secondary structures of soy allergens. ► HHP could decrease allergenicity by modifying conformation of allergenic epitopes.