کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1183045 963217 2017 8 صفحه PDF ندارد دانلود کنید
عنوان انگلیسی مقاله
Theobroma cacao extract attenuates the development of Dermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice
ترجمه فارسی عنوان
عصاره درخت کاکائو تضعیف توسعه آتوپیک به Dermatophagoides farinae ناشی از علائم درماتیت مانند در موش NC / NGA
کلمات کلیدی
CE، عصاره کاکائو؛ AD، درماتیت آتوپیک؛ DFE، به Dermatophagoides عصاره farinae؛ TEWL، از دست دادن آب transepidermal؛ TARC، تیموس و کموکاین فعال سازی تنظیم می شود. MDC، درماتیت chemokineAtopic ماکروفاژ مشتق شده؛ کاکائو؛ ارتشاح سلول های ایمنی بدن؛ Inflamm
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• CE attenuated DFE-induced AD-like symptoms.
• CE suppressed DFE-induced inflammation in the skin.
• CE alleviated DFE-induced transepidermal water loss and increased skin hydration.
• CE has potential therapeutic efficacy for the AD treatment.

Cacao beans from Theobroma cacao are an abundant source of polyphenols, particularly flavonoids. Previous studies demonstrated that cacao flavanols decrease pro-inflammatory cytokines resulting in the alleviation of allergic symptoms. We sought to investigate the effects of cacao extract (CE) on Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like symptoms. CE attenuated DFE-induced AD-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. Histopathological analysis revealed that CE suppressed DFE-induced immune cell infiltration into the skin. These observations occurred concomitantly with the downregulation of inflammatory markers including serum immunoglobulin (Ig) E, chemokine; thymus and activation-regulated chemokine and macrophage-derived chemokine as well as the skin-derived cytokines interleukin (IL)-4, IL-5, and interferon-γ. CE also significantly alleviated transepidermal water loss and increased skin hydration. These results suggest that CE, a natural phytochemical-rich food, has potential therapeutic efficacy for the treatment of AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 216, 1 February 2017, Pages 19–26
نویسندگان
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