Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh

► The mechanism of the anticancer activity of the mango peel extract was investigated. ► Both extrinsic and intrinsic pathways participate in the apoptosis of HeLa cells. ► LC-ESI-MS analysis revealed that main constituent was quercetin 3-O-galactoside. ► GC-MS analysis revealed a great amount of unsaturated fatty acids in peel extract.