A combined proteomic and genetic analysis of the highly variable platelet proteome: From plasmatic proteins and SNPs

► High variations in the platelet proteome are caused by plasmatic proteins and SNPs. ► Plasmatic proteins represent an integral part of the platelet proteome. ► SNP-induced polarity shifts in GSTO1 isoforms allow genotyping with mAb on 2D-WB. ► Allocation of GSTO1 isoforms to SNP rs4925 reduces their variation to the mean CV. ► GSTO1*delE155 does not cause protein deficiency in vivo.