Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion

► H2S decreases ROS levels in cardiomyocytes during ischemia/reperfusion. ► One mechanism is associated with inhibition of mitochondrial complex IV. ► The other mechanism is through activation of SODs. ► ITC results show direct interaction between H2S and CuZn-SOD.