کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11033906 | 1561724 | 2018 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice
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کلمات کلیدی
Heme oxygenase-1NQO1Nrf2EtOHHO-1CATGCLCADH1CYP2E1AMSALTALDHLPSDMFH&E - H & ENAD(P)H:quinone oxidoreductase 1 - NAD (P) H: کینون اکسیدوردوکتاز 1ROS - ROSALD - آدرنولکودیستروفیAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Pancreatic injury - آسیب پانکراسHepatic injury - آسیب کبدیalanine transaminase - آلانین ترانس آمینازaldehyde dehydrogenase - آلدئید دهیدروژنازamylase - آمیلازEthanol - اتانولAlcohol - الکلalcohol dehydrogenase 1 - الکل دهیدروژناز 1Alcoholism - الکلیسمalcoholic liver disease - بیماری کبدی الکلیdimethyl fumarate - دی متیل فوماراتhematoxylin and eosin staining - رنگ آمیزی هماتوکسیلین و ائوزینcytochrome P450 2E1 - سیتوکروم P450 2E1antioxidant response element - عنصر پاسخ آنتی اکسیدانLipase - لیپازglutamate-cysteine ligase - لیگاز گلوتامات سیتئینknock out - ناک اوتwild type - نوع وحشیARE - هستندCatalase - کاتالازGas chromatography - کروماتوگرافی گازیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Binge alcohol drinking is an important health concern and well-known risk factor for the development of numerous disorders. Oxidative stress plays a critical role in the pathogenesis of acute alcoholism. Nuclear factor erythroid 2 like 2 (NRF2) is a master regulator of cellular adaptive response to oxidative insults. However, the role of NRF2 in acute alcoholism and associated pathologies remains unclear. We found that Nrf2-knockout (Nrf2-KO) mice had exaggerated hypoglycemia and hypothermia and increased mortality compared to wildtype mice after binge ethanol exposure. This phenotype was partially rescued by providing warm environment and/or glucose administration. Acute high dose of alcohol exposure resulted in substantially worsened liver and pancreatic injuries in Nrf2-KO mice. Importantly, deficiency of Nrf2 allowed severe pancreatitis and pancreatic β-cell injury with increased insulin secretion and/or leaking during binge ethanol exposure, which contributed to hypoglycemia. In contrast, a clinically used NRF2 activator dimethyl fumarate (DMF) protected against hypoglycemia and lethality induced by acute ethanol exposure. Furthermore, Nrf2-KO mice likely had defective hepatic acetaldehyde metabolism. Taken together, NRF2 plays an important protective role against acute binge alcohol-induced hepatic and pancreatic damage, which may be partially attributable to its primary regulating role in antioxidant response and impact on ethanol metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 121, November 2018, Pages 495-503
Journal: Food and Chemical Toxicology - Volume 121, November 2018, Pages 495-503
نویسندگان
Jing Sun, Jingqi Fu, Yang Zhong, Lu Li, Chengjie Chen, Xiaolei Wang, Linlin Wang, Yongyong Hou, Huihui Wang, Rui Zhao, Xixuan Zhang, Masayuki Yamamoto, Yuanyuan Xu, Jingbo Pi,