کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1405070 1501707 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel 2-amino-1,3,4-thiadiazoles and their acyl derivatives: Synthesis, structural characterization, molecular docking studies and comparison of experimental and computational results
ترجمه فارسی عنوان
2-آمینو-1،3،4-تیادیازول و مشتقات آتییل آنها: سنتز، خصوصیات ساختاری، مطالعات تکاملی مولکولی و مقایسه نتایج آزمایشگاهی و محاسباتی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Novel 2-amino-1,3,4-thiadiazole and their acyl derivatives were synthesized.
• The synthesized compounds were characterized by different spectroscopic techniques.
• The crystal and molecular structures of compounds 2b and 2c were investigated.
• Molecular docking study was implemented on the compounds 2b and 2c.

This study aims to synthesize and characterize compounds containing 2-amino-1,3,4-thiadiazole and compare experimental results to theoretical results. For this purpose, firstly mono, di and tetra 2-amino-1,3,4-thiadiazole compounds (2a–c, 14, 20 and 25) were synthesized in relatively high yields (74–87%). The target compounds (3–11, 15–17, 21–23 and 26–28) were then synthesized in moderate to high yields (65–85%) from the reactions of 2-amino-1,3,4-thiadiazole compounds with various acyl chloride derivatives.The structures of all synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, elemental analyses and mass spectroscopy techniques. The structures of 2b (C9H8N4O2S) and 2c (C11H13N3O2S) were also elucidated by X-ray diffraction analysis.Lastly, IR spectrum, 1H NMR and 13C NMR chemical shift values, frontier molecular orbital (FMO) values of these molecules containing heteroatoms were examined using the Becke-3- Lee-Yang-Parr (B3LYP) method with the 6-31G(d) basis set. Two different molecular structures containing 2-amino-1,3,4-thiadiazole (2b, 2c) were used in our study to examine these properties. Also, compounds 2b and 2c form a stable complex with beta-Lactamase as can be understood from the binding affinity values and the results show that the compound might inhibit the beta-Lactamase enzyme. It was found that theoretical and experimental results obtained in the experiment were compatible with each other and with the values found in the literature.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1110, 15 April 2016, Pages 102–113
نویسندگان
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