کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1407519 | 1501690 | 2017 | 5 صفحه PDF | دانلود رایگان |
• Four chiral 4-substituted 1,2,4-triazoles have been synthesized.
• Their structures have been found from single crystal X-ray diffraction.
• Their NMR, IR and mass spectra have been acquired.
• CD reveals chirooptical properties of these molecules.
1,2,4-triazoles attract attention as actively used medications and ligands for constructing coordination architectures. In this paper we describe four optically active 4-substituted 1,2,4-triazoles that have been prepared by Bayer's synthesis from the corresponding aliphatic chiral amines. This approach tends to be universal towards different triazoles and permits to conserve a homochirality of substrates. Novel asymmetric molecules have been characterized by spectroscopic techniques and their structures have been retrieved from the single crystal X-ray analysis. Chiro-optical studies of these heterocycles have been made by means of circular dichroism spectroscopy.
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Journal: Journal of Molecular Structure - Volume 1127, 5 January 2017, Pages 164–168