N-alkylated and O-alkylated regioisomers of 5-(hydroxyalkyl)pyrimidines: Synthesis and structural study

► Syntheses of C-5 hydroxyalkyl N- and O-acyclic pyrimidine nucleosides are reported. ► Regioisomers are assigned on the basis of 1H-13C correlation signals in 2D HMBC spectra. ► X-ray crystal structural analyses of 5-(acetoxyalkyl)-4-methoxypyrimidin-2-ones are presented.