Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents

• A series of Mn(II) complexes were intercalated into the hydroxy double salt [Zn5(OH)8]Cl·yH2O.
• Clear evidence for partial replacement of Cl− by the complexes was seen.
• The HDS/Mn(II) complex composites have great potential as MRI contrast agents.

A series of Mn(II) aminophosphonate complexes were successfully synthesized and intercalated into the hydroxy double salt [Zn5(OH)8]Cl2·yH2O. Complex incorporation led to an increase in the interlayer spacing from 7.8 to 10–12 Å. Infrared spectroscopy showed the presence of the characteristic vibration peaks of the Mn(II) complexes in the intercalates' spectra, indicating successful incorporation. The complex-loaded composites had somewhat lower proton relaxivities than the pure complexes. Nevertheless, these intercalates may have use as MRI contrast agents for patients with poor kidney function, where traditional Gd(III)-based contrast agents cause severe renal failure.

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