Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats

► The protective effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell injury were confirmed by histopathological analyses. ► Oxidative stress markers including malondialdehyde, superoxide dismutase, catalase and glutathione, in cerebellum were determined. ► The neuroprotective mechanism was discussed in the view of antioxidative system. ► Chlorogenic acid could be beneficial for prevention from the side-effects of chemotherapeutics.