کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2076301 | 1079436 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A trade-off relationship between energetic cost and entropic cost for in vitro evolution
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A trade-off relationship between energetic cost and entropic cost for in vitro evolution A trade-off relationship between energetic cost and entropic cost for in vitro evolution](/preview/png/2076301.png)
چکیده انگلیسی
In this paper, we consider two complementary cost functions for the landscape exploring processes to obtain the global optimum sequence through in vitro evolution protocol: one is the entropic cost Cetp, which is based on the deviation from the uniformity of a mutant distribution in sequence space, and the other is the energetic cost Ceng, which is based on the total number of sequences to be generated and evaluated. Based on a prior knowledge about the structure of a given fitness landscapes, the conductor of the experiment can think up the efficient search algorithm (ESA), which requires the minimum number of points (=sequences) to be searched up to the global optimum. For five typical fitness landscapes, we considered their respective (putative) ESA, Cetp* and Ceng* based on the ESA. As a result, we found a trade-off relationship between Cetp* and Ceng* for every case, that is, Ceng*+Cetp* is approximately equal to the logarithm of the volume of the sequence space. Cetp* and Ceng* are interpreted in terms of the information-theoretic concepts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 101, Issue 3, September 2010, Pages 194-199
Journal: Biosystems - Volume 101, Issue 3, September 2010, Pages 194-199
نویسندگان
Takuyo Aita,