کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2592640 | 1132036 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Twenty-eight-day oral toxicity study of lycopene from recombinant Escherichia coli in rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lycopene produced by recombinant Escherichia coli was tested for subacute oral toxicity to determine its No-Observed-Adverse-Effect Level (NOAEL). Doses of 0, 200, 500 and 2000Â mg/kg body weight/day were administered daily by gavage to 10 rats/sex/group for 28 days. No statistically significant, dose-related effect on body weight gain, clinical signs or ophthalmoscopic parameters was observed in any treatment group. Likewise, no treatment-related or dose-related toxic effect was found in hematology, clinical chemistry, urinalysis, blood coagulation, organ weight, gross observation or histopathology. Thus, the NOAEL for lycopene derived from recombinant Escherichia coli was at least 2000Â mg/kg body weight/day.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 52, Issue 2, November 2008, Pages 163-168
Journal: Regulatory Toxicology and Pharmacology - Volume 52, Issue 2, November 2008, Pages 163-168
نویسندگان
Wen-Chi Jian, Ming-Hsi Chiou, Yung-Tin Chen, Chi-Nan Lin, Mei-Chiao Wu, Chi-Jen Du, Cleo Chen-Pan,