کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2647741 1139067 2013 8 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers
ترجمه فارسی عنوان
تغییرات ژنی سیتوکین با مسیرهای علائم افسردگی در بیماران سرپایی و مراقبان خانوادگی در ارتباط است
کلمات کلیدی
افسردگی؛ سرطان؛ سیتوکین ها؛ ژنتیک؛ مدل سازی مخلوط رشد؛ مراقبان خانواده؛ پرتو درمانی
Depression; Cancer; Cytokines; Genetics; Growth mixture modeling; Family caregivers; Radiation therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

PurposeDepressive symptoms are common in cancer patients and their family caregivers (FCs). While these symptoms are characterized by substantial interindividual variability, the factors that predict this variability remain largely unknown. This study sought to confirm latent classes of oncology patients and FCs with distinct depressive symptom trajectories and to examine differences in phenotypic and genotypic characteristics among these classes.MethodAmong 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on Center for Epidemiological Studies-Depression (CES-D) scores obtained prior to, during, and for four months following completion of radiation therapy. One hundred four single nucleotide polymorphisms (SNPs) and haplotypes in 15 candidate cytokine genes were interrogated for differences between the two largest latent classes. Multivariate logistic regression analyses assessed effects of phenotypic and genotypic characteristics on class membership.ResultsFour latent classes were confirmed: Resilient (56.3%), Subsyndromal (32.5%), Delayed (5.2%), and Peak (6.0%). Participants who were younger, female, non-white, and who reported higher baseline trait and state anxiety were more likely to be in the Subsyndromal, Delayed, or Peak groups. Variation in three cytokine genes (i.e., interleukin 1 receptor 2 [IL1R2], IL10, tumor necrosis factor alpha [TNFA]), age, and performance status predicted membership in the Resilient versus Subsyndromal classes.ConclusionsFindings confirm the four latent classes of depressive symptom trajectories previously identified in a sample of breast cancer patients. Variations in cytokine genes may influence variability in depressive symptom trajectories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Oncology Nursing - Volume 17, Issue 3, June 2013, Pages 346–353
نویسندگان
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