کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4356163 | 1615666 | 2007 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns
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کلمات کلیدی
DnmtMECPPRMTsprotein arginine methyltransferases5-azaCJmjCPAD4PresbycusisTrxG5-Aza-dCLSD1NF2ICFPcGHDACiSAMHDACCpGDNA methyltransferase - DNA متیل ترانسفرازSmall interfering RNA - RNA تداخل کوچکmicro RNA - RNA میکروS-adenosyl-L-methionine - S-adenosyl-L-metionineSINEs - SINE هاsiRNA - siRNAorgan of Corti - اندام کورتیHistone modifications - تغییرات هیستونLines - خطوطFacioScapuloHumeral Muscular Dystrophy - دیستروفی عضلانی FacioScapuloHumeralSchwann cell - سلول شوانHair cells - سلول های مویVestibular schwannoma - شوانومای وستیبولارDNA methylation - متیلاسیون DNAhistone deacetylase inhibitor - مهار کننده هیستون داسیدلازMiRNA - میکروRNA، ریزآرانای، miRNAdeafness - ناشنواییneurofibromatosis type 2 - نوروفیبروماتوز نوع 2Histone - هیستونhistone acetyltransferases - هیستون استیل ترانسفرازhistone deacetylase - هیستون داستیلازPolycomb group protein - پروتئین گروه پلی کامبHAT - کلاه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epigenetics is a large and diverse field encompassing a number of different mechanisms essential to development, DNA stability and gene expression. DNA methylation and histone modifications work individually and in conjunction with each other leading to phenotypic changes. An overwhelming amount of evidence exists demonstrating the essential nature of epigenetics to human biology and pathology. This field has spawned a vast array of knowledge, techniques and pharmaceuticals designed to investigate and manipulate epigenetic phenomena. Despite its centricity to molecular biology, little work has been conducted examining how epigenetics affects hearing. In this review, we discuss both the basic tenets of epigenetics and highlight the most recent advances in this field. We discuss its importance to human development, genomic stability, gene expression, epigenetic modifying agents as well as briefly introduce the expansive field of cancer epigenetics. We then examine the evidence of a role for epigenetics in hearing related processes and hearing loss. The article concludes with a discussion of areas of epigenetic research that could be applied to hearing research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 233, Issues 1â2, November 2007, Pages 1-13
Journal: Hearing Research - Volume 233, Issues 1â2, November 2007, Pages 1-13
نویسندگان
Matthew J. Provenzano, Frederick E. Domann,