|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|4909567||1427343||2018||7 صفحه PDF||سفارش دهید||دانلود کنید|
- Supercritical Carbon Dioxide (SFCO2) Artemisinin extraction from CIM-Arogya.
- Hexane Soxhlet Artemisinin extraction from CIM-Arogya.
- Crude Soxhlet Artemisinin extracts, adsorbed on silica gel, treated with SFCO2.
- In desorption runs extracts collected and analiysed at different intervals of time.
- Desorption trials correlated with different models.
Artemisinin is a drug for chloroquine resistant malaria and cerebral malaria treatments. In the recent past, there was an acute shortage of this drug and hence World Health Organization made a strategy to fulfil the Artemisinin demand.In this study, artemisinin was extracted by supercritical Carbon Dioxide (SFCO2) from CIM-Arogya, a variety of Artemisia annua, in temperature and pressure ranges of 313.1-333.1Â K and 15-25Â MPa. Artemisinin global yield isotherms were determined obtaining a maximum yield of 3.65Â wt%. Artemisinin extracts were also obtained by hexane Soxhlet extraction: then, the crude extracts were purified using SFCO2, after adsorption on silica gel. Different desorption runs were performed with a 6Â ml/min CO2 flow rate, in temperature and pressure ranges of 313.1-333.1Â K and 15-25Â MPa. At different time intervals, extracts were collected and analysed: their yields varied from 2.75% to 4.34% function of the experimental conditions. Desorption trials were also correlated with different models.
Journal: The Journal of Supercritical Fluids - Volume 133, Part 1, March 2018, Pages 42-48