کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5132635 1492050 2018 6 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats
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موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats
چکیده انگلیسی


- TP nanoemulsion with particle size about 100 nm was prepared.
- TP nanoemulsion is stable during 20 days' storage.
- Nanoemulsion improved the oral bioavailability of EGCG and EGC.

Tea polyphenols (TP) were emulsified with corn oil and polysorbate 80 by high-pressure homogenization. The oil in water (O/W) TP nanoemulsion had droplet sizes of 99.42 ± 1.25 nm after preparation. The TP nanoemulsion was stable during storage at 4, 25 or 40 °C for 20 days. An in vitro simulated digestion assay showed that the bioaccessibility of (−)-epigallocatechin gallate (EGCG) was increased in the nanoemulsion compared to that in aqueous solution, but that the bioaccessibilities of (−)-epigallocatechin (EGC), (−)-epicatechin (EC) and (−)-gallocatechin gallate (GCG) were greatly decreased. Compared with rats fed an aqueous TP solution, rats fed the TP nanoemulsion had significantly lower maximum plasma concentrations (Cmax) of EGCG and EGC, but the area under the plasma concentration-time curve (AUC0-t) was increased. The data show that use of a nanoemulsion system to deliver tea polyphenols may enhance the absorption of EGCG through controlled release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 242, 1 March 2018, Pages 527-532
نویسندگان
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