کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5746495 1618796 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity
ترجمه فارسی عنوان
پاسخ های عصبی در بافت های مغز ماهی قزل آلا رنگین کمان در معرض آفت کش های ایمیداکلوپرید: ارزیابی فعالیت هشت هیدروکسی 2-دگزسی گوانوزین، استرس اکسیداتیو و فعالیت استیلکولین استراز
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- We investigated neurotoxic responses by observing 8-OHdG activity, oxidative stress and AChE activity in fish brain exposed to imidacloprid.
- Imidacloprid exposure caused an increase in 8-OHdG activity and immunopositiv reaction for 8-OHdG was detected in brain tissues.
- Imidacloprid exposure induces AChE inhibition in brain tissues.

The extensive use of imidacloprid, a neonicotinoid insecticide, causes undesirable toxicity in non-targeted organisms including fish in aquatic environments. We investigated neurotoxic responses by observing 8-hydroxy-2-deoxyguanosine (8-OHdG) activity, oxidative stress and acetylcholinesterase (AChE) activity in rainbow trout brain tissue after 21 days of imidacloprid exposure at levels of (5 mg/L, 10 mg/L, 20 mg/L). The obtained results indicated that 8-OHdG activity did not change in fish exposed to 5 mg/L of imidacloprid, but 10 mg/L and 20 mg/L of imidacloprid significantly increased 8-OHdG activity compared to the control (p < 0.05). An immunopositiv reaction to 8-OHdG was detected in brain tissues. The brain tissues indicated a significant increase in antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)) compared to the control and there was a significant increase in malondialdehyde (MDA) levels (p < 0.05). High concentrations of imidacloprid caused a significant decrease in AChE enzyme activity (p < 0.05). These results suggested that imidacloprid can be neurotoxic to fish by promoting AChE inhibition, an increase in 8-OHdG activity and changes in oxidative stress parameters. Therefore, these data may reflect one of the molecular pathways that play a role in imidacloprid toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 175, May 2017, Pages 186-191
نویسندگان
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