کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5908726 | 1570164 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection
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کلمات کلیدی
IFNL4CHCRBVinterleukin-28BULNALTRBCWBCIL28BEVRSVRRVRGGTcEVRETVRAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازtriglyceride - تریگلیسریدUpper limit of normal - حد بالای طبیعیRibavirin - ریباویرین body mass index - شاخص توده بدنBMI - شاخص توده بدنیconfidence interval - فاصله اطمینانTreatment outcome - نتیجه درمانodds ratio - نسبت شانس هاHemoglobin - هموگلوبینHgb - هورمون رشدchronic hepatitis C - هپاتیت C مزمنHepatitis C virus - هپاتیت سیHCV - هپاتیت سیRapid virological response - پاسخ سریع ویروسیearly virological response - پاسخ ویروسی زودرسSustained virologic response - پاسخ پایدار ویروسیcomplete early virological response - پاسخ کامل ویروسی بالینی را کامل کنیدSpontaneous clearance - پاکسازی خود به خودیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدSerum total cholesterol - کلسترول کلسترول سرمGamma-glutamyl transferase - گاما گلوتامیل ترانسفرازwhite blood cell - گلبول سفید خونred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recently, the dinucleotide variant ss469415590 (TT/ÎG) in a novel gene, interferon lambda 4 (IFNL4), was identified as a stronger predictor of hepatitis C virus (HCV) clearance in individuals of African ancestry compared with rs12979860. We aimed to determine whether this variant contributes to treatment decisions in a Chinese population. A total of 447 chronic hepatitis C (CHC) patients (including 328 treated with interferon alpha-2b and ribavirin), 129 individuals who had spontaneously cleared HCV (SHC), and 169 healthy controls were retrospectively investigated. ss469415590 genotyping was performed using a mass spectrometry method (SEQUENOM). A higher proportion of SHC individuals carried the TT/TT genotype compared with CHC patients (95.3% vs. 88.8%, P = 0.027). In patients with HCV genotype 1b, the ss469415590 variant was independently associated with sustained virologic response (SVR) (odds ratio [OR] = 3.247, 95% confidence interval [CI] = 1.038-10.159, P = 0.043) and on-treatment virological responses, including rapid (RVR), complete early (cEVR), early (EVR), and end-of-treatment (ETVR), with a minimal OR of 3.73. Especially for patients with high viral load (â¥Â 4 Ã 105 IU/ml), ÎG allele carriers had a lower chance of achieving SVR compared with those carrying the TT/TT genotype (7.1% vs. 36.0%, P = 0.034, OR [95% CI] = 7.24 [1.02-318.45], negative predictive value = 92.9%). In patients with HCV genotype 2a, no significant association between the ss154949590 variant and the virological response was identified (P > 0.05). Additionally, we found that ss154949590 was in complete linkage disequilibrium with rs12979860. In conclusion, the IFNL4 ss154949590 TT/TT genotype favors spontaneous clearance of HCV. This same variant is associated with treatment-induced clearance in patients with genotype 1b, but not 2a. ss469415590 (or rs12979860) genotyping should be considered for patients with HCV genotype 1b and high viral load when making a choice between standard dual therapy and an IFN-free direct-acting antiviral regimen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 39, April 2016, Pages 132-140
Journal: Infection, Genetics and Evolution - Volume 39, April 2016, Pages 132-140
نویسندگان
Ruihong Wu, Xiumei Chi, Xiaomei Wang, Haibo Sun, Juan Lv, Xiuzhu Gao, Ge Yu, Fei Kong, Hongqin Xu, Rui Hua, Jing Jiang, Bing Sun, Jin Zhong, Yu Pan, Junqi Niu,