کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282701 | 1615145 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-κB p65 under ER stress in mouse hypothalamic cultures
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کلمات کلیدی
NF-κBDEXNPYAgRPtunicamycinUPRThapsigarginp38 MAPK - P38 MAPKEndoplasmic reticulum stress - استرس شبکه آندوپلاسمیDexamethasone - دگزامتازونendoplasmic reticulum - شبکه آندوپلاسمی Unfolded protein response - پاسخ پروتئین آشکارAgouti-related protein - پروتئین مرتبط با Agoutip38 mitogen-activated protein kinases - پروتئین کیناز متیوژن فعال P38Glucocorticoids - گلوکوکورتیکوئیدهاglucocorticoid receptor - گیرنده گلوکوکورتیکوئیدNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
There are several lines of evidence suggesting that glucocorticoid signaling in the hypothalamus plays an important role in energy balance, and recent studies suggest that endoplasmic reticulum (ER) stress in the hypothalamus could affect signaling related to energy balance. In the present study, we examined the regulation of glucocorticoid signaling under ER stress in mouse hypothalamic organotypic cultures. Incubation of the hypothalamic explants with dexamethasone (DEX) significantly increased expression levels of neuropeptide Y (NPY) and agouti-related protein (AgRP) mRNA, and treatment with thapsigargin (TG), an ER stressor, significantly attenuated DEX-induced NPY and AgRP mRNA expression. TG treatment increased the levels of phospho-NF-κB p65 in hypothalamic cultures, and inhibitors of NF-κB p65 reversed the inhibitory effects of TG on NPY and AgRP expression. Our data thus demonstrated that glucocorticoid-stimulated NPY and AgRP expression was attenuated via NF-κB p65 pathways under ER stress, and suggest crosstalk between ER stress and inflammation in the hypothalamus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 553, 11 October 2013, Pages 165-169
Journal: Neuroscience Letters - Volume 553, 11 October 2013, Pages 165-169
نویسندگان
Shigeru Hagimoto, Hiroshi Arima, Koichi Adachi, Yoshihiro Ito, Hidetaka Suga, Yoshihisa Sugimura, Motomitsu Goto, Ryoichi Banno, Yutaka Oiso,