Lipid-polymer hybrid nanoparticles with rhamnolipid-triggered release capabilities as anti-biofilm drug delivery vehicles

► Poly(lactic-co-glycolic acid) and phosphatidylcholine are used as the polymer nanoparticle core and lipid coat for the hybrid nanoparticles. ► The rhamnolipid-triggered release capability of the hybrid nanoparticles enables the targeted release of the encapsulated BCS Class III drug in the vicinity of biofilm colonies. ► The rate of the triggered release can be controlled by incorporating an additional lipid layer on the hybrid nanoparticles.