Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment

A novel chemotherapeutic (CDDP)-siRNA (HuR) combination was tested for its anti-tumor efficiency in lung cancer cells using folic acid conjugated Dendrimer-Polyethlyeneimine (Den-PEI) nanoparticles. This Den-PEI-CDDP-HuR-FA system showed favorable properties for targeted delivery and enhanced cell uptake in folate receptor alpha (FRA) overexpressing lung cancer cells. The targeted nanoparticle delivery also induced apoptosis, and demonstrated efficient combined therapeutic activity of CDDP and HuR siRNA in lung cancer cells.271