کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7597633 | 1492135 | 2014 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin
ترجمه فارسی عنوان
افزایش قابلیت زیستی و بهبود زیستی پراکندگی جامد غیرمستقیم کورکومین
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Curcumin has been shown to have a wide variety of biological activities for various human diseases including inflammation, diabetes and cancer. However, the poor oral bioavailability of curcumin poses a significant pharmacological barrier to its use therapeutically and/or as a functional food. Here we report the evaluation of the bioavailability and bio-efficacy of curcumin as an amorphous solid dispersion (ASD) in a matrix consisting of hydroxypropyl methyl cellulose (HPMC), lecithin and isomalt using hot melt extrusion for application in food products. Oral pharmacokinetic studies in rats showed that ASD curcumin was â¼13-fold more bioavailable compared to unformulated curcumin. Evaluation of the anti-inflammatory activity of ASD curcumin in vivo demonstrated enhanced bio-efficacy compared to unformulated curcumin at 10-fold lower dose. Thus ASD curcumin provides a more potent and efficacious formulation of curcumin which may also help in masking the colour, taste and smell which currently limit its application as a functional food ingredient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 156, 1 August 2014, Pages 227-233
Journal: Food Chemistry - Volume 156, 1 August 2014, Pages 227-233
نویسندگان
Ai Mey Chuah, Bindya Jacob, Zhang Jie, Subbarayan Ramesh, Shibajee Mandal, Jithesh K. Puthan, Parag Deshpande, Vadakkanchery V. Vaidyanathan, Richard W. Gelling, Gaurav Patel, Tapas Das, Sathyavageeswaran Shreeram,