کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7783501 | 1500572 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel in situ forming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery
ترجمه فارسی عنوان
رون در محل تشکیل هیدروژل بر اساس زانتان و کیتوزان مجددا ژلینگ در مایعات برای تحویل دارو محلی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
هیدروژل تزریقی خود شفا، تحویل مواد مخدر، صمغ زانتان، هیدرولیز ضد آنزیمی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Injectable hydrogels have been an attractive topic in biomaterials. However, during gelation in vivo, they are easy to disperse due to tissue exudates, thus leading to failure of controlled drug release. To solve this problem, we present a novel polysaccharide-based injectable hydrogel via self-crosslinking of aldehyde-modified xanthan (Xan-CHO) and carboxymethyl-modified chitosan (NOCC). The physical properties were optimized by adjusting the mass ratio of Xan-CHO and NOCC. Experiments revealed that this material exhibited the characteristics of self-healing, anti-enzymatic hydrolysis, biocompatibility and biodegradability. The releasing curve demonstrated stable release of BSA-FITC within 10â¯h after injection in liquids. After incorporation with a vascular endothelial growth factor, there was an interaction between this biomaterial and the host, which accelerated the reconstruction of the abdominal wall in rats. Therefore, this injectable hydrogel, as a drug delivery system, can prevent drug outburst in a variety of settings and function as a tissue scaffold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 186, 15 April 2018, Pages 54-63
Journal: Carbohydrate Polymers - Volume 186, 15 April 2018, Pages 54-63
نویسندگان
Jinjian Huang, Youming Deng, Jianan Ren, Guopu Chen, Gefei Wang, Feng Wang, Xiuwen Wu,