کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8268903 | 1534956 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes
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کلمات کلیدی
MDRDANCOVAMAFACENADPHAOPPEGFRMPO - DFOROS - ROSangiotensin converting enzyme - آنزیم تبدیل آنژیوتانسینGenetic association - ارتباط ژنتیکیUAE - امارات متحده عربیNADPH oxidase - اکسیداز NADPH ESRD یا end stage renal disease - بیماری کلیوی در مرحله نهایی End-stage renal disease - بیماری کلیوی در مرحله پایانیanalysis of covariance - تجزیه و تحلیل کوواریانسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceOxidative stress - تنش اکسیداتیوUrinary albumin excretion - دفع آلبومین ادرارconfidence intervals - فاصله اطمینانminor allele frequency - فراوانی آللی جزئیadvanced oxidation protein products - محصولات پیشرفته اکسیداسیون پروتئینProspective cohort study - مطالعه کوهورت چشمگیرUTR یا untranslated regions - منطقه ترجمه نشدهuntranslated region - منطقه غیر ترجمهestimated glomerular filtration rate - میزان تصفیه گلومرولی برآورد شده استmyeloperoxidase - میلوپراکسیداز hazard ratio - نسبت خطرodds ratio - نسبت شانس هاDiabetic nephropathy - نفروپاتی دیابتیnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oxidative stress plays a pivotal role in the pathophysiology of diabetic nephropathy, and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system is an important source of reactive oxygen species in hyperglycemic conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in patients with diabetic nephropathy. We investigated associations of variants in the CYBA gene, encoding the regulatory subunit p22phox of NADPH oxidase, with diabetic nephropathy and plasma AOPP and myeloperoxidase (MPO) concentrations in type 1 diabetic patients. Seven SNPs in the CYBA region were analyzed in 1357 Caucasian subjects with type 1 diabetes from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of diabetic nephropathy. The major G-allele of rs9932581 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of nephropathy during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced nephropathy (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of end-stage renal disease (ESRD) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma MPO concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the CYBA gene was associated with lower eGFR and with prevalence and incidence of diabetic nephropathy and ESRD in type 1 diabetic patients. These results are consistent with a role for NADPH oxidase in the pathophysiology of kidney complications of diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 86, September 2015, Pages 16-24
Journal: Free Radical Biology and Medicine - Volume 86, September 2015, Pages 16-24
نویسندگان
Thiago A. Patente, Kamel Mohammedi, Naïma Bellili-Muñoz, Fathi Driss, Manuel Sanchez, Frédéric Fumeron, Ronan Roussel, Samy Hadjadj, Maria Lúcia Corrêa-Giannella, Michel Marre, Gilberto Velho,