کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839893 | 1613763 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury
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کلمات کلیدی
TNFMMPMDANeuNMEPDAPI4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولSpinal cord injury - آسیب نخاعیneuronal nuclear antigen - آنتی ژن هسته ای نورونEdaravone - اداروونهinterleukin - اینترلوکینBasso-Beattie-Bresnahan - باسو بیتی برسنهانFunctional recovery - بهبود عملکردanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceBBB - سد خونی مغزیsci - علمیtumor necrosis factor - فاکتور نکروز تومورmatrix metalloproteinase - ماتریکس متالوپروتئینازmalonyldialdehyde - مالونی دی آلدئیدMethylprednisolone - متیل پردنیزولونNeuroprotection - محافظت نورونی یا محافظت از عصبMPs - نمایندگان مجلسmotor-evoked potential - پتانسیل حرکت موتورmotor-evoked potentials - پتانسیل حرکت موتورLipid peroxidation - پراکسیداسیون لیپیدChAT - چتcholine acetyltransferase - کولین استیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We used a multimodal approach to evaluate the effects of edaravone in a rat model of spinal cord injury (SCI). SCI was induced by extradural compression of thoracic spinal cord. In experiment 1, 30â¯min prior to compression, rats received a 3â¯mg/kg intravenous bolus of edaravone followed by a maintenance infusion of 1 (low-dose), 3 (moderate-dose), or 10 (high-dose) mg/kg/h edaravone. Although both moderate- and high-dose edaravone regimens promoted recovery of spinal motor-evoked potentials (MEPs) at 2â¯h post-SCI, the effect of the moderate dose was more pronounced. In experiment 2, moderate-dose edaravone was administered 30â¯min prior to compression, at the start of compression, or 10â¯min after decompression. Although both preemptive and coincident administration resulted in significantly improved spinal MEPs at 2â¯h post-SCI, the effect of preemptive administration was more pronounced. A moderate dose of edaravone resulted in significant attenuation of lipid peroxidation, as evidenced by lower concentrations of the free radical malonyldialdehyde in the spinal cord 3â¯h post-SCI. Malonyldialdehyde levels in the high-dose edaravone group were not reduced. Both moderate- and high-dose edaravone resulted in significant functional improvements, evidenced by better Basso-Beattie-Bresnahan (BBB) scores and better performance on an inclined plane during an 8â¯week period post-SCI. Both moderate- and high-dose edaravone significantly attenuated neuronal loss in the spinal cord at 8â¯weeks post-SCI, as evidenced by quantitative immunohistochemical analysis of NeuN-positive cells. In conclusion, early administration of a moderate dose of edaravone minimized the negative consequences of SCI and facilitated functional recovery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1682, 1 March 2018, Pages 24-35
Journal: Brain Research - Volume 1682, 1 March 2018, Pages 24-35
نویسندگان
Hideaki Ishii, Andrey B. Petrenko, Mika Sasaki, Yukio Satoh, Yoshinori Kamiya, Toshiyuki Tobita, Kenta Furutani, Mari Matsuhashi, Tatsuro Kohno, Hiroshi Baba,