کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9001462 | 1118521 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Very stable superoxide radical adducts of 5-ethoxycarbonyl- 3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives
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کلمات کلیدی
5,5-dimethylpyrroline N-oxideDMPO5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxideEMPODEPMPODTPAHFSnuclear magnetic resonance - رزونانس مغناطیسی هستهایO2•− - O2 • -NMR - تشدید مغناطیسی هستهای EPR - تشدید پارامغناطیس الکترونElectron paramagnetic resonance - تشدید پارامغناطیس الکترونHyperfine splitting - تقسیم HyperfineSpin traps - تله چرخشDiethylenetriaminepentaacetic acid - دی اتیلنتریمین پنتا اسیدهای اسیدFree radicals - رادیکال آزادSuperoxide anion radical - رادیکال آنیون سوپراکسیدSOD - سدSuperoxide - سوپر اکسیدSuperoxide dismutase - سوکسوکس دیسموتازLinoleic acid hydroperoxide - هیدروپراکسید اسید لینولئیک
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oxygen radicals are involved in the onset of many diseases. Adequate spin traps are required for identification and localisation of free radical formation in biological systems. Superoxide spin adducts with half-lives up to 20Â min at physiological pH have recently been reported to be formed from derivatives of the spin trap 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO). This is a major improvement over DMPO (t1/2 ca. 45Â s), and even DEPMPO (t1/2 ca. 14Â min). In this study, an additional methyl group was introduced into position 3 or 4 of the pyrroline ring which greatly increases the stability of the respective superoxide spin adducts. In addition, the ethoxy group of EMPO was exchanged by either a propoxy- or an iso-propoxy group in order to test the influence of increasing lipophilic properties of the investigated spin traps. The structure of all compounds was confirmed by 1H and 13C-NMR with full signal assignment. In comparison with EMPO (t1/2 ca. 8Â min) or DEPMPO (t1/2 ca. 14Â min), the superoxide adducts of all novel spin traps were considerably higher (t1/2 ca. 12-55Â min). In addition, various other spin adducts obtained from oxygen-centered as well as carbon-centered radicals (e.g. derived from methanol or linoleic acid hydroperoxide) were also detected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 69, Issue 9, 1 May 2005, Pages 1351-1361
Journal: Biochemical Pharmacology - Volume 69, Issue 9, 1 May 2005, Pages 1351-1361
نویسندگان
Klaus Stolze, Natascha Rohr-Udilova, Thomas Rosenau, Roswitha Stadtmüller, Hans Nohl,