Impregnation of dimeric CrIII(salen) on silica and its application in epoxide asymmetric ring opening reactions

The heterogeneous asymmetric ring opening (ARO) of epoxides with trimethylsilylazide (TMSN3) catalysed by a dimeric Cr(salen) catalyst impregnated on a silica material combines high enantioselectivities for epoxide and ring opened product with good conversions and suffers only from low leaching in both batch and continuous flow experiments.