SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer Fulltext Access 14 Pages 2018
Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors Fulltext Access 14 Pages 2018
Synthesis and biological characterization of ubenimex-fluorouracil conjugates for anti-cancer therapy Fulltext Access 14 Pages 2018
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection Fulltext Access 14 Pages 2018
Secretion and function of Cln5 during the early stages of Dictyostelium development Fulltext Access 14 Pages 2018
The origin of GSKIP, a multifaceted regulatory factor in the mammalian Wnt pathway Fulltext Access 14 Pages 2018
Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R Fulltext Access 14 Pages 2018
RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell Fulltext Access 14 Pages 2018
Subpopulations of extracellular vesicles and their therapeutic potential Fulltext Access 14 Pages 2018
Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action Fulltext Access 14 Pages 2018
A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer Fulltext Access 14 Pages 2018
Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass Fulltext Access 14 Pages 2018
Serum responsive proteome reveals correlation between oxidative phosphorylation and morphogenesis in Candida albicans ATCC10231 Fulltext Access 14 Pages 2018
HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction Fulltext Access 14 Pages 2018
p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice Fulltext Access 14 Pages 2018
Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity Fulltext Access 14 Pages 2018
CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis Fulltext Access 14 Pages 2018
Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder Fulltext Access 14 Pages 2018
Up-regulated expression of SNHG6 predicts poor prognosis in colorectal cancer Fulltext Access 14 Pages 2018
SATB2 is a supportive marker for the differentiation of a primary mucinous tumor of the ovary and an ovarian metastasis of a low-grade appendiceal mucinous neoplasm (LAMN): A series of seven cases Fulltext Access 14 Pages 2018
Suppression of PTBP1 signaling is responsible for mesenchymal stem cell induced invasion of low malignancy cancer cells Fulltext Access 14 Pages 2018
Towards Acacia seyal protocol in Sudan: Preliminary study pertinent to colour identification and physiochemical properties Fulltext Access 14 Pages 2018
Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis Fulltext Access 14 Pages 2018
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages Fulltext Access 14 Pages 2018
Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress Fulltext Access 14 Pages 2018
Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A Fulltext Access 14 Pages 2018
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA Fulltext Access 14 Pages 2018
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy Fulltext Access 14 Pages 2018
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents Fulltext Access 14 Pages 2018
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α) Fulltext Access 14 Pages 2018
Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam Fulltext Access 14 Pages 2018
Systems analysis of singly and multiply O-glycosylated peptides in the human serum glycoproteome via EThcD and HCD mass spectrometry Fulltext Access 14 Pages 2018
Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies Fulltext Access 14 Pages 2018
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation Fulltext Access 14 Pages 2018
Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer Fulltext Access 14 Pages 2018
Children with type 1 Gaucher disease: Changing profiles in the 21st century Fulltext Access 15 Pages 2018
Novel mutations in mitochondrial carrier family gene SLC25A38, causing congenital sideroblastic anemia in Iranian families, identified by whole exome sequencing Fulltext Access 15 Pages 2018
Caspase -1, -3, -8 and antioxidant enzyme genes are key molecular effectors following Vibrio parahaemolyticus and Aeromonas veronii infection in fish leukocytes Fulltext Access 15 Pages 2018
Aberrant promoter methylation of the PAQR3 gene is associated with prostate cancer Fulltext Access 15 Pages 2018
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) Fulltext Access 15 Pages 2018
Speed matters to raise molar radioactivity: Fast HPLC shortens the quality control of C-11 PET-tracers Fulltext Access 15 Pages 2018
Heme oxygenase-1 protects bone marrow mesenchymal stem cells from iron overload through decreasing reactive oxygen species and promoting IL-10 generation Fulltext Access 15 Pages 2018
ATP/P2X7-NLRP3 axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion Fulltext Access 15 Pages 2018
Autophagy attenuates compression-induced apoptosis of human nucleus pulposus cells via MEK/ERK/NRF1/Atg7 signaling pathways during intervertebral disc degeneration Fulltext Access 15 Pages 2018
A case of influenza type a myocarditis that presents with ST elevation MI, cardiogenic shock, acute renal failure, and rhabdomyolysis and with rapid recovery after treatment with oseltamivir and intra-aortic balloon pump support Fulltext Access 15 Pages 2018
Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet Fulltext Access 15 Pages 2018
Small nucleolar RNA host gene 1: A new biomarker and therapeutic target for cancers Fulltext Access 15 Pages 2018
The Long Noncoding RNA MEG3 and its Target miR-147 Regulate JAK/STAT Pathway in Advanced Chronic Myeloid Leukemia Fulltext Access 15 Pages 2018
iTRAQ-based analysis of the Arabidopsis proteome reveals insights into the potential mechanisms of anthocyanin accumulation regulation in response to phosphate deficiency Fulltext Access 15 Pages 2018
O-GlcNAcylation site mapping by (azide-alkyne) click chemistry and mass spectrometry following intensive fractionation of skeletal muscle cells proteins Fulltext Access 15 Pages 2018
CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway Fulltext Access 15 Pages 2018
Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma Fulltext Access 15 Pages 2018
CircSEMA4B targets miR-431 modulating IL-1β-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway Fulltext Access 15 Pages 2018
Establishing life is a calcium-dependent TRiP: Transient receptor potential channels in reproduction Fulltext Access 15 Pages 2018
Control of SUMO and Ubiquitin by ROS: Signaling and disease implications Fulltext Access 15 Pages 2018
Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells Fulltext Access 15 Pages 2018
Synthesis and biological evaluation of aurora kinases inhibitors based on N-trisubstituted pyrimidine scaffold Fulltext Access 15 Pages 2018
4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection Fulltext Access 15 Pages 2018
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity Fulltext Access 15 Pages 2018
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7 Fulltext Access 15 Pages 2018
Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts Fulltext Access 15 Pages 2018
Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death Fulltext Access 15 Pages 2018
β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin Fulltext Access 15 Pages 2018
Characterization of somatostatin receptors and associated signaling pathways in pancreas of R6/2 transgenic mice Fulltext Access 15 Pages 2018
Protein Kinase C-ζ stimulates colorectal cancer cell carcinogenesis via PKC-ζ/Rac1/Pak1/β-Catenin signaling cascade Fulltext Access 15 Pages 2018
Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold Fulltext Access 15 Pages 2018
Microfluidic single-cell technology in immunology and antibody screening Fulltext Access 15 Pages 2018
Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression Fulltext Access 15 Pages 2018
Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis Fulltext Access 15 Pages 2018
Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands Fulltext Access 15 Pages 2018
Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance Fulltext Access 15 Pages 2018
IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells Fulltext Access 15 Pages 2018
Revealing critical mechanisms of BR-mediated apple nursery tree growth using iTRAQ-based proteomic analysis Fulltext Access 16 Pages 2018
Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis Fulltext Access 16 Pages 2018
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development Fulltext Access 16 Pages 2018
ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration Fulltext Access 16 Pages 2018
Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage Fulltext Access 16 Pages 2018
Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells Fulltext Access 16 Pages 2018
DN604: A platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells Fulltext Access 16 Pages 2018
Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors Fulltext Access 16 Pages 2018
Enterococcus faecalis immunoregulates osteoclastogenesis of macrophages Fulltext Access 16 Pages 2018
Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones Fulltext Access 16 Pages 2018
Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus Fulltext Access 16 Pages 2018
Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery Fulltext Access 16 Pages 2018
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network Fulltext Access 16 Pages 2018
Bone marrow miR-10a overexpression is associated with genetic events but not affects clinical outcome in acute myeloid leukemia Fulltext Access 16 Pages 2018
Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity Fulltext Access 16 Pages 2018
Investigation of BRAF V600E detection approaches in papillary thyroid carcinoma Fulltext Access 16 Pages 2018
Clinicopathological features of low-grade malignant endolymphatic sac tumors Fulltext Access 16 Pages 2018
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds Fulltext Access 16 Pages 2018
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties Fulltext Access 16 Pages 2018