Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor Fulltext Access 42 Pages 2018
Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor Fulltext Access 42 Pages 2018
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models Fulltext Access 42 Pages 2018
C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease Fulltext Access 43 Pages 2018
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections Fulltext Access 43 Pages 2018
Synthesis and antiproliferative activity of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 1,8-naphthyridin-2-one moiety Fulltext Access 43 Pages 2018
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B Fulltext Access 43 Pages 2018
Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors Fulltext Access 43 Pages 2018
Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound Fulltext Access 43 Pages 2018
Degradation of fibrin-β amyloid co-aggregate: A novel function attributed to ubiquitin Fulltext Access 43 Pages 2018
Discovery of novel human inosine 5â²-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents Fulltext Access 43 Pages 2018
A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation Fulltext Access 43 Pages 2018
Anti-amyloidogenic and anti-apoptotic effect of α-bisabolol against Aβ induced neurotoxicity in PC12 cells Fulltext Access 43 Pages 2018
Sox9 is increased in arterial plaque and stenosis, associated with synthetic phenotype of vascular smooth muscle cells and causes alterations in extracellular matrix and calcification Fulltext Access 43 Pages 2018
Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression Fulltext Access 43 Pages 2018
Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-κB pathway Fulltext Access 43 Pages 2018
The A to Z of modulated cell patterning by mammalian thioredoxin reductases Fulltext Access 43 Pages 2018
A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer Fulltext Access 43 Pages 2018
Oxidative cross-linking of proteins to DNA following ischemia-reperfusion injury Fulltext Access 43 Pages 2018
TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis Fulltext Access 43 Pages 2018
Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity Fulltext Access 43 Pages 2018
Oxidative stress reduces trophoblast FOXO1 and integrin β3 expression that inhibits cell motility Fulltext Access 43 Pages 2018
Preparation of Rhodium(III) complexes with 2(1H)-quinolinone derivatives and evaluation of their in vitro and in vivo antitumor activity Fulltext Access 43 Pages 2018
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP) Fulltext Access 43 Pages 2018
IFNÏ mediates chemotaxis, motility, metabolism and CK18 downregulation in bovine trophoblast cells in vitro via STAT1 and MAPK42/44 signaling Fulltext Access 43 Pages 2018
Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects Fulltext Access 43 Pages 2018
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity Fulltext Access 43 Pages 2018
γ-Tubulin has a conserved intrinsic property of self-polymerization into double stranded filaments and fibrillar networks Fulltext Access 43 Pages 2018
Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy Fulltext Access 43 Pages 2018
3D-cultured neural stem cell microarrays on a micropillar chip for high-throughput developmental neurotoxicology Fulltext Access 43 Pages 2018
New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress Fulltext Access 43 Pages 2018
Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens Fulltext Access 43 Pages 2018
Identification of a novel trafficking pathway exporting a replication protein, Orc2 to nucleus via classical secretory pathway in Plasmodium falciparum Fulltext Access 43 Pages 2018
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration Fulltext Access 43 Pages 2018
Hepatitis B core protein promotes liver cancer metastasis through miR-382-5p/DLC-1 axis Fulltext Access 43 Pages 2018
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity Fulltext Access 43 Pages 2018
Recent updates for designing CCR5 antagonists as anti-retroviral agents Fulltext Access 43 Pages 2018
Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling Fulltext Access 44 Pages 2018
Aquaporin-1 and -5 are involved in the invasion and proliferation of soft tissue sarcomas Fulltext Access 44 Pages 2018
Redox tuning of Ca2+ signaling in microglia drives glutamate release during hypoxia Fulltext Access 44 Pages 2018
Mechanistic study of nonivamide enhancement of hyperthermia-induced apoptosis in U937 cells Fulltext Access 44 Pages 2018
Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis Fulltext Access 44 Pages 2018
Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies Fulltext Access 44 Pages 2018
F8 inversions of introns 22 and 1 confer a moderate risk of inhibitors in Mexican patients with severe hemophilia A. Concordance analysis and literature review Fulltext Access 44 Pages 2018
AMPKα2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction Fulltext Access 44 Pages 2018
Comparison of outcomes in new-generation versus early-generation heart valve in transcatheter aortic valve implantation: A systematic review and meta-analysis Fulltext Access 44 Pages 2018
A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors Fulltext Access 44 Pages 2018
Synthesis and photodynamic activities of integrin-targeting silicon(IV) phthalocyanine-cRGD conjugates Fulltext Access 44 Pages 2018
Discovery of the selective and efficacious inhibitors of FLT3 mutations Fulltext Access 44 Pages 2018
N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines Fulltext Access 44 Pages 2018
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors Fulltext Access 44 Pages 2018
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase Fulltext Access 44 Pages 2018
Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors Fulltext Access 44 Pages 2018
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives Fulltext Access 44 Pages 2018
Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans Fulltext Access 44 Pages 2018
Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells Fulltext Access 44 Pages 2018
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line Fulltext Access 44 Pages 2018
Synthesis and molecular docking of new roflumilast analogues as preferential-selective potent PDE-4B inhibitors with improved pharmacokinetic profile Fulltext Access 44 Pages 2018
Biotin conjugated organic molecules and proteins for cancer therapy: A review Fulltext Access 44 Pages 2018
Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping Fulltext Access 44 Pages 2018
4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer Fulltext Access 44 Pages 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease Fulltext Access 44 Pages 2018
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin Fulltext Access 44 Pages 2018
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease Fulltext Access 44 Pages 2018
Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome Fulltext Access 44 Pages 2018
Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish Fulltext Access 44 Pages 2018
Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages Fulltext Access 44 Pages 2018
Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c Fulltext Access 44 Pages 2018
Mechanisms of DNA damage repair in adult stem cells and implications for cancer formation Fulltext Access 44 Pages 2018
The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact Fulltext Access 44 Pages 2018
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines Fulltext Access 45 Pages 2018
Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells Fulltext Access 45 Pages 2018
Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance Fulltext Access 45 Pages 2018
NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity Fulltext Access 45 Pages 2018
Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents Fulltext Access 45 Pages 2018
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype Fulltext Access 45 Pages 2018
Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism Fulltext Access 45 Pages 2018
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal Fulltext Access 45 Pages 2018
Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation Fulltext Access 45 Pages 2018
Synthesis and characterization of nitrile functionalized silver(I)-N-heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus Fulltext Access 45 Pages 2018
Design and synthesis of aryloxypropanolamine as β3-adrenergic receptor antagonist in cancer and lipolysis Fulltext Access 45 Pages 2018
Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives Fulltext Access 45 Pages 2018
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cel Fulltext Access 45 Pages 2018
Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties Fulltext Access 45 Pages 2018
Discovery of naphtho[1,2-d]oxazole derivatives as potential anti-HCV agents through inducing heme oxygenase-1 expression Fulltext Access 45 Pages 2018
LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR signaling pathway Fulltext Access 45 Pages 2018
Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway Fulltext Access 45 Pages 2018
S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis Fulltext Access 45 Pages 2018
Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes Fulltext Access 45 Pages 2018
Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain Fulltext Access 45 Pages 2018
Novel short isoforms of adenylyl cyclase as negative regulators of cAMP production Fulltext Access 45 Pages 2018
Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR Fulltext Access 45 Pages 2018
Nitric oxide regulates chlorophyllide biosynthesis and singlet oxygen generation differently between Arabidopsis and barley Fulltext Access 45 Pages 2018
A sense oligonucleotide to inducible nitric oxide synthase mRNA increases the survival rate of rats in septic shock Fulltext Access 45 Pages 2018