Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome Fulltext Access 45 Pages 2018
Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition Fulltext Access 45 Pages 2018
Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis Fulltext Access 45 Pages 2018
Dermal fibroblast-to-myofibroblast transition sustained by αvÃ3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders Fulltext Access 45 Pages 2018
Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial Fulltext Access 45 Pages 2018
Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke Fulltext Access 45 Pages 2018
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease Fulltext Access 45 Pages 2018
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis Fulltext Access 45 Pages 2018
Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling Fulltext Access 45 Pages 2018
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease Fulltext Access 46 Pages 2018
The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis Fulltext Access 46 Pages 2018
Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells Fulltext Access 46 Pages 2018
Post-transplant cholangiopathy: Classification, pathogenesis, and preventive strategies Fulltext Access 46 Pages 2018
Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways Fulltext Access 46 Pages 2018
Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression Fulltext Access 46 Pages 2018
Up-regulation of NOX1/NADPH oxidase following drug-induced myocardial injury promotes cardiac dysfunction and fibrosis Fulltext Access 46 Pages 2018
SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death Fulltext Access 46 Pages 2018
Atomic structure and enzymatic insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit C Fulltext Access 46 Pages 2018
Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase Fulltext Access 46 Pages 2018
Multi-Site Diagnostic Classification of Schizophrenia Using Discriminant Deep Learning with Functional Connectivity MRI Fulltext Access 46 Pages 2018
Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation Fulltext Access 46 Pages 2018
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis Fulltext Access 46 Pages 2018
Recent developments on synthesis and biological activities of γ-carboline Fulltext Access 46 Pages 2018
Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity Fulltext Access 46 Pages 2018
Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase Fulltext Access 46 Pages 2018
Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d]pyrimidine analogues as novel CHK1 inhibitors Fulltext Access 46 Pages 2018
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses Fulltext Access 46 Pages 2018
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production Fulltext Access 46 Pages 2018
Rational design of carbamate-based dual binding site and central AChE inhibitors by a “biooxidisable” prodrug approach: Synthesis, in vitro evaluation and docking studies Fulltext Access 46 Pages 2018
((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies Fulltext Access 46 Pages 2018
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway Fulltext Access 46 Pages 2018
Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors Fulltext Access 46 Pages 2018
Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles Fulltext Access 47 Pages 2018
Molecular dissection of the membrane aggregation mechanisms induced by monomeric annexin A2 Fulltext Access 47 Pages 2018
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside Fulltext Access 47 Pages 2018
Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4â²-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4â²-demethylepipodophyllotoxin Fulltext Access 47 Pages 2018
Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo Fulltext Access 47 Pages 2018
Coexistence of multiple globin genes conferring protection against nitrosative stress to the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 Fulltext Access 47 Pages 2018
RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison Fulltext Access 47 Pages 2018
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines Fulltext Access 47 Pages 2018
Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2 Fulltext Access 47 Pages 2018
Preliminary evaluation of 18F-labeled LLP2A-trifluoroborate conjugates as VLA-4 (α4β1 integrin) specific radiotracers for PET imaging of melanoma Fulltext Access 47 Pages 2018
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice Fulltext Access 47 Pages 2018
Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands Fulltext Access 47 Pages 2018
Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library Fulltext Access 47 Pages 2018
Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells Fulltext Access 47 Pages 2018
Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity Fulltext Access 47 Pages 2018
Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting Fulltext Access 47 Pages 2018
A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis Fulltext Access 47 Pages 2018
Arylureas derived from colchicine: Enhancement of colchicine oncogene downregulation activity Fulltext Access 47 Pages 2018
Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes Fulltext Access 48 Pages 2018
Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders Fulltext Access 48 Pages 2018
HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters Fulltext Access 48 Pages 2018
ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury Fulltext Access 48 Pages 2018
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors Fulltext Access 48 Pages 2018
Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism Fulltext Access 48 Pages 2018
New hydrazides derivatives of isoniazid against Mycobacterium tuberculosis: Higher potency and lower hepatocytotoxicity Fulltext Access 48 Pages 2018
Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites Fulltext Access 48 Pages 2018
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain Fulltext Access 48 Pages 2018
In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways Fulltext Access 48 Pages 2018
Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors Fulltext Access 48 Pages 2018
High resolution top-down experimental strategies on the Orbitrap platform Fulltext Access 48 Pages 2018
Antiproliferative hydrogen sulfide releasing evodiamine derivatives and their apoptosis inducing properties Fulltext Access 48 Pages 2018
Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction Fulltext Access 48 Pages 2018
Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy Fulltext Access 48 Pages 2018
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability Fulltext Access 48 Pages 2018
The rice cold-responsive calcium-dependent protein kinase OsCPK17 is regulated by alternative splicing and post-translational modifications Fulltext Access 48 Pages 2018
Autophagy activation is required for influenza A virus-induced apoptosis and replication Fulltext Access 49 Pages 2018
Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones Fulltext Access 49 Pages 2018
Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents Fulltext Access 49 Pages 2018
O2-(2,4-dinitrophenyl)diazeniumdiolates derivatives: Design, synthesis, cytotoxic evaluation and reversing MDR in MCF-7/ADR cells Fulltext Access 49 Pages 2018
The inhibition of sphingomyelin synthase 1 activity induces collecting duct cells to lose their epithelial phenotype Fulltext Access 49 Pages 2018
BODIPYs to the rescue: Potential applications in photodynamic inactivation Fulltext Access 49 Pages 2018
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors Fulltext Access 49 Pages 2018
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation Fulltext Access 49 Pages 2018
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element Fulltext Access 49 Pages 2018
Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells Fulltext Access 49 Pages 2018
Proteomic identification of virulence-related factors in young and aging C. elegans infected with Pseudomonas aeruginosa Fulltext Access 49 Pages 2018
Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease Fulltext Access 49 Pages 2018
Caffeic acid attenuates rat liver injury after transplantation involving PDIA3-dependent regulation of NADPH oxidase Fulltext Access 50 Pages 2018
Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide Fulltext Access 50 Pages 2018
Longissimus dorsi muscle label-free quantitative proteomic reveals biological mechanisms associated with intramuscular fat deposition Fulltext Access 50 Pages 2018
Axin-2 knockdown promote mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/β-catenin signaling in rat model of Parkinson's disease Fulltext Access 50 Pages 2018
Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359 Fulltext Access 50 Pages 2018
Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts Fulltext Access 50 Pages 2018
FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential Fulltext Access 50 Pages 2018
Polysulfides and products of H2S/S-nitrosoglutathione in comparison to H2S, glutathione and antioxidant Trolox are potent scavengers of superoxide anion radical and produce hydroxyl radical by decomposition of H2O2 Fulltext Access 50 Pages 2018
Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating Fulltext Access 50 Pages 2018