Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors Fulltext Access 50 Pages 2018
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors Fulltext Access 50 Pages 2018
New 1,5 and 2,5-disubstituted tetrazoles-dependent activity towards surface barrier of Candida albicans Fulltext Access 50 Pages 2018
A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors Fulltext Access 50 Pages 2018
Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells Fulltext Access 50 Pages 2018
Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell Fulltext Access 50 Pages 2018
NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma Fulltext Access 50 Pages 2018
Secretome from hypoxia-conditioned adipose-derived mesenchymal stem cells promotes the healing of gastric mucosal injury in a rodent model Fulltext Access 50 Pages 2018
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors Fulltext Access 50 Pages 2018
An access to a library of novel triterpene derivatives with a promising pharmacological potential by Ugi and Passerini multicomponent reactions Fulltext Access 51 Pages 2018
Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2) Fulltext Access 51 Pages 2018
NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation Fulltext Access 51 Pages 2018
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase Fulltext Access 51 Pages 2018
Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies Fulltext Access 51 Pages 2018
A comparative proteomic characterization and nutritional assessment of naturally- and artificially-cultivated Cordyceps sinensis Fulltext Access 51 Pages 2018
iTRAQ-based quantitative proteomic analysis reveals pathways associated with re-establishing desiccation tolerance in germinating seeds of Caragana korshinskii Kom. Fulltext Access 51 Pages 2018
Comparative proteomic analysis of chief and oxyphil cell nodules in refractory uremic hyperparathyroidism by iTRAQ coupled LC-MS/MS Fulltext Access 51 Pages 2018
HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches Fulltext Access 51 Pages 2018
Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model Fulltext Access 52 Pages 2018
Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers Fulltext Access 52 Pages 2018
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors Fulltext Access 52 Pages 2018
AMPK activation promotes gastroprotection through mutual interaction with the gaseous mediators H2S, NO, and CO Fulltext Access 52 Pages 2018
Aggregation of α- and β- caseins induced by peroxyl radicals involves secondary reactions of carbonyl compounds as well as di-tyrosine and di-tryptophan formation Fulltext Access 52 Pages 2018
Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway Fulltext Access 52 Pages 2018
Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines Fulltext Access 52 Pages 2018
PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation Fulltext Access 52 Pages 2018
The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs Fulltext Access 52 Pages 2018
Cytotoxicity of η6-areneruthenium-based molecules to glioblastoma cells and their recognition by multidrug ABC transporters Fulltext Access 52 Pages 2018
Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway Fulltext Access 52 Pages 2018
Design, synthesis, and biological evaluation of stable β6.3-Helices: Discovery of non-hemolytic antibacterial peptides Fulltext Access 52 Pages 2018
Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors Fulltext Access 52 Pages 2018
Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig Fulltext Access 52 Pages 2018
β-Lapachone and its iodine derivatives cause cell cycle arrest at G2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells Fulltext Access 52 Pages 2018
The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease Fulltext Access 52 Pages 2018
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity Fulltext Access 52 Pages 2018
Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo Fulltext Access 52 Pages 2018
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus Fulltext Access 52 Pages 2018
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors Fulltext Access 52 Pages 2018
Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents Fulltext Access 52 Pages 2018
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis Fulltext Access 52 Pages 2018
ROS-dependent signalling pathways in plants and algae exposed to high light: Comparisons with other eukaryotes Fulltext Access 52 Pages 2018
PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway Fulltext Access 53 Pages 2018
Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity Fulltext Access 53 Pages 2018
Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation Fulltext Access 53 Pages 2018
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis Fulltext Access 53 Pages 2018
Hepatitis B virus promotes proliferation and metastasis in male Chinese hepatocellular carcinoma patients through the LEF-1/miR-371a-5p/SRCIN1/pleiotrophin/Slug pathway Fulltext Access 53 Pages 2018
Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus Fulltext Access 53 Pages 2018
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA) Fulltext Access 53 Pages 2018
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome Fulltext Access 53 Pages 2018
New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship Fulltext Access 53 Pages 2018
Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis Fulltext Access 53 Pages 2018
Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails Fulltext Access 53 Pages 2018
Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies Fulltext Access 53 Pages 2018
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation Fulltext Access 53 Pages 2018
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study Fulltext Access 53 Pages 2018
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs Fulltext Access 53 Pages 2018
Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET Fulltext Access 54 Pages 2018
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin Fulltext Access 54 Pages 2018
Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells Fulltext Access 54 Pages 2018
Cln3 function is linked to osmoregulation in a Dictyostelium model of Batten disease Fulltext Access 54 Pages 2018
Intact cell MALDI-TOF mass spectrometry on single bovine oocyte and follicular cells combined with top-down proteomics: A novel approach to characterise markers of oocyte maturation Fulltext Access 54 Pages 2018
Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/β-catenin pathway Fulltext Access 54 Pages 2018
Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease Fulltext Access 54 Pages 2018
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates Fulltext Access 54 Pages 2018
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential Fulltext Access 54 Pages 2018
Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury Fulltext Access 55 Pages 2018
Effects of Fe and Mn deficiencies on the protein profiles of tomato (Solanum lycopersicum) xylem sap as revealed by shotgun analyses Fulltext Access 55 Pages 2018
Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents Fulltext Access 55 Pages 2018
ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism Fulltext Access 55 Pages 2018
Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site Fulltext Access 55 Pages 2018
Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification Fulltext Access 55 Pages 2018
Novel tacrine platinum(II) complexes display high anticancer activity via inhibition of telomerase activity, dysfunction of mitochondria, and activation of the p53 signaling pathway Fulltext Access 55 Pages 2018
Novel pyrimidinic selenourea induces DNA damage, cell cycle arrest, and apoptosis in human breast carcinoma Fulltext Access 55 Pages 2018
Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents Fulltext Access 55 Pages 2018
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition Fulltext Access 55 Pages 2018
New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells Fulltext Access 55 Pages 2018
Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease Fulltext Access 55 Pages 2018
RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling Fulltext Access 55 Pages 2018
Peramivir conjugates as orally available agents against influenza H275Y mutant Fulltext Access 55 Pages 2018
Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds Fulltext Access 55 Pages 2018
Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs Fulltext Access 56 Pages 2018
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors Fulltext Access 56 Pages 2018
Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease Fulltext Access 56 Pages 2018
Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth Fulltext Access 56 Pages 2018
Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazoleâcarbazole ligands Fulltext Access 56 Pages 2018
Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity Fulltext Access 56 Pages 2018
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation Fulltext Access 56 Pages 2018
Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway Fulltext Access 56 Pages 2018
Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer Fulltext Access 56 Pages 2018
Molecular mechanisms involved in epidermal growth factor receptor-mediated inhibition of dopamine D3 receptor signaling Fulltext Access 56 Pages 2018
Secreted protein extract analyses present the plant pathogen Alternaria alternata as a suitable industrial enzyme toolbox Fulltext Access 56 Pages 2018
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel Fulltext Access 57 Pages 2018