Synthesis and biological evaluation of β2-adrenoceptor agonists bearing the 2-amino-2-phenylethanol scaffold Fulltext Access 57 Pages 2018
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition Fulltext Access 57 Pages 2018
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents Fulltext Access 57 Pages 2018
Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-α administration differ during wound repair and regeneration Fulltext Access 58 Pages 2018
Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors Fulltext Access 58 Pages 2018
Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation Fulltext Access 58 Pages 2018
Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities Fulltext Access 58 Pages 2018
Perinatal α-tocopherol overload programs alterations in kidney development and renal angiotensin II signaling pathways at birth and at juvenile age: Mechanisms underlying the development of elevated blood pressure Fulltext Access 58 Pages 2018
Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies Fulltext Access 58 Pages 2018
Characterization of IgG N-glycome profile in colorectal cancer progression by MALDI-TOF-MS Fulltext Access 58 Pages 2018
An iridium (III) complex as potent anticancer agent induces apoptosis and autophagy in B16â¯cells through inhibition of the AKT/mTOR pathway Fulltext Access 58 Pages 2018
Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs Fulltext Access 58 Pages 2018
Meiotic development initiation in the fungus Podospora anserina requires the peroxisome receptor export machinery Fulltext Access 59 Pages 2018
Structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of inhibitors of RET and its drug resistance mutants Fulltext Access 59 Pages 2018
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect Fulltext Access 59 Pages 2018
Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability Fulltext Access 59 Pages 2018
Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors Fulltext Access 59 Pages 2018
Diterpenoid lead stevioside and its hydrolysis products steviol and isosteviol: Biological activity and structural modification Fulltext Access 59 Pages 2018
Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase Fulltext Access 59 Pages 2018
Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis Fulltext Access 59 Pages 2018
Design, synthesis, biological evaluation and molecular modeling of novel 2-amino-4-(1-phenylethoxy) pyridine derivatives as potential ROS1 inhibitors Fulltext Access 59 Pages 2018
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects Fulltext Access 60 Pages 2018
Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells Fulltext Access 60 Pages 2018
The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a Fulltext Access 61 Pages 2018
Design, synthesis, and biological evaluation of novel catecholopyrimidine based PDE4 inhibitor for the treatment of atopic dermatitis Fulltext Access 61 Pages 2018
Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2â²-deoxy-2â²-fluoro- 4â²-azido nucleoside derivatives as potent anti-HBV agents Fulltext Access 61 Pages 2018
A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease Fulltext Access 61 Pages 2018
Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs Fulltext Access 61 Pages 2018
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus Fulltext Access 61 Pages 2018
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio Fulltext Access 62 Pages 2018
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors Fulltext Access 62 Pages 2018
Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity Fulltext Access 62 Pages 2018
Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1 Fulltext Access 62 Pages 2018
Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation Fulltext Access 62 Pages 2018
Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1 Fulltext Access 63 Pages 2018
Synthesis, characterization and anticancer activity in vitro and in vivo evaluation of an iridium (III) polypyridyl complex Fulltext Access 63 Pages 2018
FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission Fulltext Access 63 Pages 2018
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2 nACh receptors Fulltext Access 63 Pages 2018
Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals Fulltext Access 63 Pages 2018
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK Fulltext Access 64 Pages 2018
Benzo[d]thiazole-2-carbanilides as new anti-TB chemotypes: Design, synthesis, biological evaluation, and structure-activity relationship Fulltext Access 64 Pages 2018
H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems Fulltext Access 65 Pages 2018
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors Fulltext Access 65 Pages 2018
Synthesis of a 3â²-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides Fulltext Access 65 Pages 2018
Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells Fulltext Access 65 Pages 2018
Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state Fulltext Access 65 Pages 2018
Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors Fulltext Access 67 Pages 2018
Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents Fulltext Access 67 Pages 2018
DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective Fulltext Access 67 Pages 2018
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ÎMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense Fulltext Access 67 Pages 2018
The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts Fulltext Access 68 Pages 2018
Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection Fulltext Access 68 Pages 2018
Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance Fulltext Access 68 Pages 2018
Reformation in chimeric antigen receptor based cancer immunotherapy: Redirecting natural killer cell Fulltext Access 69 Pages 2018
Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode Fulltext Access 69 Pages 2018
Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics Fulltext Access 69 Pages 2018
Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation Fulltext Access 70 Pages 2018
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position Fulltext Access 70 Pages 2018
Nitric oxide-mediated integrative alterations in plant metabolism to confer abiotic stress tolerance, NO crosstalk with phytohormones and NO-mediated post translational modifications in modulating diverse plant stress Fulltext Access 71 Pages 2018
Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities Fulltext Access 72 Pages 2018
Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics Fulltext Access 72 Pages 2018
Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis Fulltext Access 73 Pages 2018
Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity Fulltext Access 73 Pages 2018
Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery Fulltext Access 75 Pages 2018
Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives Fulltext Access 75 Pages 2018
Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas Fulltext Access 76 Pages 2018
Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups Fulltext Access 77 Pages 2018
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analog Fulltext Access 78 Pages 2018
β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities Fulltext Access 78 Pages 2018
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease Fulltext Access 79 Pages 2018
Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1 Fulltext Access 81 Pages 2018
Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) Fulltext Access 81 Pages 2018
Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells Fulltext Access 83 Pages 2018
Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship Fulltext Access 83 Pages 2018
Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7 Fulltext Access 86 Pages 2018
Design, synthesis and structureâactivity relationship studies of GPR40 agonists containing amide linker Fulltext Access 86 Pages 2018
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents Fulltext Access 91 Pages 2018
Amphiphilic glycoconjugates as potential anti-cancer chemotherapeutics Fulltext Access 103 Pages 2018
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “bio-oxidizable” prodrugs: Synthesis, biological evaluation and structure-activity relationship Fulltext Access 107 Pages 2018
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools Fulltext Access 108 Pages 2018
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors Fulltext Access 194 Pages 2018
Original articleA TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer Fulltext Access 4 Pages 2017
Food for thought: Autophagy researcher wins 2016 Nobel Prize in Physiology or Medicine Fulltext Access 4 Pages 2017
Horning cell self-digestion: Autophagy wins the 2016 Nobel Prize in Physiology or Medicine Fulltext Access 4 Pages 2017
A six-year longitudinal PET study of (+)-[11C]DTBZ binding to the VMAT2 in monkey brain Fulltext Access 4 Pages 2017
Estimation of radiation dosimetry for 68Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer Fulltext Access 4 Pages 2017
Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand Fulltext Access 4 Pages 2017
Original articleThe diagnostic role of plasma circulating precursors of miRNA-944 and miRNA-3662 for non-small cell lung cancer detection Fulltext Access 4 Pages 2017
Original articleOver-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value Fulltext Access 4 Pages 2017
Case reportSynchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review Fulltext Access 4 Pages 2017
Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway Fulltext Access 4 Pages 2017
ReviewPP2A regulates signaling through hormonal receptors in breast cancer with important therapeutic implications Fulltext Access 4 Pages 2017