Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival Fulltext Access 40 Pages 2018
The 5T4 oncofetal glycoprotein does not act as a general organizer of the CXCL12 system in cancer cells Fulltext Access 40 Pages 2018
Synthesis of novel Chlorin e6-curcumin conjugates as photosensitizers for photodynamic therapy against pancreatic carcinoma Fulltext Access 40 Pages 2018
cxcl12 gene engineered endothelial progenitor cells further improve the functions of oligodendrocyte precursor cells Fulltext Access 40 Pages 2018
Structure-based development of an osteoprotegerin-like glycopeptide that blocks RANKL/RANK interactions and reduces ovariectomy-induced bone loss in mice Fulltext Access 40 Pages 2018
In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs Fulltext Access 40 Pages 2018
Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation Fulltext Access 40 Pages 2018
Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors Fulltext Access 40 Pages 2018
Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model Fulltext Access 40 Pages 2018
19q13.12 microdeletion syndrome fibroblasts display abnormal storage of cholesterol and sphingolipids in the endo-lysosomal system Fulltext Access 40 Pages 2018
Deficiency of S100B confers resistance to experimental diabetes in mice Fulltext Access 40 Pages 2018
Interaction of arsenic with gap junction protein connexin 43 alters gap junctional intercellular communication Fulltext Access 40 Pages 2018
Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content Fulltext Access 40 Pages 2018
PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p Fulltext Access 40 Pages 2018
Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice Fulltext Access 40 Pages 2018
Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation Fulltext Access 40 Pages 2018
A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells Fulltext Access 40 Pages 2018
High- and low-affinity PEGylated hemoglobin-based oxygen carriers: Differential oxidative stress in a Guinea pig transfusion model Fulltext Access 40 Pages 2018
Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2 Fulltext Access 40 Pages 2018
Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents Fulltext Access 40 Pages 2018
Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation Fulltext Access 40 Pages 2018
Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation Fulltext Access 40 Pages 2018
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity Fulltext Access 40 Pages 2018
The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes Fulltext Access 40 Pages 2018
1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity Fulltext Access 40 Pages 2018
Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA) Fulltext Access 40 Pages 2018
FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway Fulltext Access 40 Pages 2018
Difuran-substituted quinoxalines as a novel class of PI3Kα H1047R mutant inhibitors: Synthesis, biological evaluation and structure-activity relationship Fulltext Access 40 Pages 2018
Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1 Fulltext Access 40 Pages 2018
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold Fulltext Access 40 Pages 2018
CCL2 conditionally determines CCL22-dependent Th2-accumulation during TGF-β-induced breast cancer progression Fulltext Access 40 Pages 2018
Synthesis and evaluation of a novel urea-based 68Ga-complex for imaging PSMA binding in tumor Fulltext Access 40 Pages 2018
Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo Fulltext Access 40 Pages 2018
SUSD2 promotes cancer metastasis and confers cisplatin resistance in high grade serous ovarian cancer Fulltext Access 40 Pages 2018
Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties Fulltext Access 41 Pages 2018
Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway Fulltext Access 41 Pages 2018
A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products Fulltext Access 41 Pages 2018
Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor Fulltext Access 41 Pages 2018
Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids Fulltext Access 41 Pages 2018
MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease Fulltext Access 41 Pages 2018
Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/β-catenin signaling pathways Fulltext Access 41 Pages 2018
Heterochromatin protein (HP)1γ is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments Fulltext Access 41 Pages 2018
Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia - A novel tool to study the impaired cargo transmission of the placenta to the maternal organs Fulltext Access 41 Pages 2018
The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration Fulltext Access 41 Pages 2018
Role of upregulated miR-136-5p in lung adenocarcinoma: A study of 1242 samples utilizing bioinformatics analysis Fulltext Access 41 Pages 2018
Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells Fulltext Access 41 Pages 2018
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity Fulltext Access 41 Pages 2018
Chemokine CC-motif ligand 2 participates in platelet function and arterial thrombosis by regulating PKCα-P38MAPK-HSP27 pathway Fulltext Access 41 Pages 2018
Structure-based discovery of cytotoxic dimeric tetrahydroxanthones as potential topoisomerase I inhibitors from a marine-derived fungus Fulltext Access 41 Pages 2018
A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates Fulltext Access 41 Pages 2018
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity Fulltext Access 41 Pages 2018
Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors Fulltext Access 41 Pages 2018
Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy Fulltext Access 41 Pages 2018
Synthesis and study of benzofuran-pyran analogs as BMP-2 targeted osteogenic agents Fulltext Access 41 Pages 2018
Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria Fulltext Access 41 Pages 2018
Mitochondrial pore opening and loss of Ca2Â + exchanger NCLX levels occur after frataxin depletion Fulltext Access 41 Pages 2018
Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone Fulltext Access 41 Pages 2018
Serum proteome profiling in canine idiopathic dilated cardiomyopathy using TMT-based quantitative proteomics approach Fulltext Access 41 Pages 2018
Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons Fulltext Access 42 Pages 2018
Redox responses are preserved across muscle fibres with differential susceptibility to aging Fulltext Access 42 Pages 2018
Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors Fulltext Access 42 Pages 2018
The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review Fulltext Access 42 Pages 2018
Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS Fulltext Access 42 Pages 2018
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor Fulltext Access 42 Pages 2018
Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle Fulltext Access 42 Pages 2018
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone Fulltext Access 42 Pages 2018
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines Fulltext Access 42 Pages 2018
Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection Fulltext Access 42 Pages 2018
Side effects of methotrexate therapy for rheumatoid arthritis: AÂ systematic review Fulltext Access 42 Pages 2018
Identification and efficacy of glycine, serine and threonine metabolism in potentiating kanamycin-mediated killing of Edwardsiella piscicida Fulltext Access 42 Pages 2018
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site Fulltext Access 42 Pages 2018
Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake Fulltext Access 42 Pages 2018
Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators Fulltext Access 42 Pages 2018
Comparative proteomics of the larval and adult stages of the model cestode parasite Mesocestoides corti Fulltext Access 42 Pages 2018
Browning of white adipose tissue induced by the Ã3 agonist CL-316,243 after local and systemic treatment - PK-PD relationship Fulltext Access 42 Pages 2018
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice Fulltext Access 42 Pages 2018
Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease Fulltext Access 42 Pages 2018
N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione Fulltext Access 42 Pages 2018
Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response Fulltext Access 42 Pages 2018
NADPH oxidase 4 and endothelial nitric oxide synthase contribute to endothelial dysfunction mediated by histone methylations in metabolic memory Fulltext Access 42 Pages 2018
Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts Fulltext Access 42 Pages 2018
TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy Fulltext Access 42 Pages 2018
STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells Fulltext Access 42 Pages 2018
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p Fulltext Access 42 Pages 2018
Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway Fulltext Access 42 Pages 2018
New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity Fulltext Access 42 Pages 2018
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition Fulltext Access 42 Pages 2018
A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic Fulltext Access 42 Pages 2018
Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R Fulltext Access 42 Pages 2018
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast Fulltext Access 42 Pages 2018
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII Fulltext Access 42 Pages 2018
Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model Fulltext Access 42 Pages 2018
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors Fulltext Access 42 Pages 2018
Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents Fulltext Access 42 Pages 2018