Vangl2 is essential for myocardial remodeling activated by Wnt/JNK signaling Fulltext Access 35 Pages 2018
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability Fulltext Access 35 Pages 2018
Synthesis and biological evaluation of α-santonin derivatives as anti-hepatoma agents Fulltext Access 35 Pages 2018
Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines Fulltext Access 35 Pages 2018
Transcriptome analysis identifies genes involved in sex determination and development of Xenopus laevis gonads Fulltext Access 35 Pages 2018
Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells Fulltext Access 35 Pages 2018
Hypoxia-induced autophagy activation through NF-κB pathway regulates cell proliferation and migration to induce pulmonary vascular remodeling Fulltext Access 35 Pages 2018
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors Fulltext Access 35 Pages 2018
VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells Fulltext Access 35 Pages 2018
PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH Fulltext Access 35 Pages 2018
Monitoring autophagic flux using p62/SQSTM1 based luciferase reporters in glioma cells Fulltext Access 35 Pages 2018
Regulation of human placental drug transporters in HCV infection and their influence on direct acting antiviral medications Fulltext Access 35 Pages 2018
Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor metastasis Fulltext Access 35 Pages 2018
Synthesis, characterization and ROS-mediated antitumor effects of palladium(II) complexes of curcuminoids Fulltext Access 35 Pages 2018
Identification of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamate-nitrostyrene hybrid as potent antiproliferative and apoptotic inducing agent against cervical cancer cell lines Fulltext Access 35 Pages 2018
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors Fulltext Access 35 Pages 2018
Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity Fulltext Access 35 Pages 2018
5â²-Chloro-2,2â²-dihydroxychalcone and related flavanoids as treatments for prostate cancer Fulltext Access 35 Pages 2018
Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers Fulltext Access 36 Pages 2018
Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile Fulltext Access 36 Pages 2018
BMP signaling-driven osteogenesis is critically dependent on Prdx-1 expression-mediated maintenance of chondrocyte prehypetrophy Fulltext Access 36 Pages 2018
Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development Fulltext Access 36 Pages 2018
Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans Fulltext Access 36 Pages 2018
Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking Fulltext Access 36 Pages 2018
RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis Fulltext Access 36 Pages 2018
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis Fulltext Access 36 Pages 2018
Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model Fulltext Access 36 Pages 2018
Genetic determinants of cholangiopathies: Molecular and systems genetics Fulltext Access 36 Pages 2018
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations Fulltext Access 36 Pages 2018
2,4âDiâtertâbutylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells Fulltext Access 36 Pages 2018
Treatments of tilapia (Oreochromis niloticus) using nitric oxide for quality improvement: Establishing a potential method for large-scale processing of farmed fish Fulltext Access 36 Pages 2018
Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity Fulltext Access 36 Pages 2018
Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment Fulltext Access 36 Pages 2018
Myosin Id localizes in dendritic spines through the tail homology 1 domain Fulltext Access 36 Pages 2018
Inhibition of TGF-β pathway reverts extracellular matrix remodeling in T. cruzi-infected cardiac spheroids Fulltext Access 36 Pages 2018
Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365 Fulltext Access 36 Pages 2018
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection Fulltext Access 36 Pages 2018
LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling Fulltext Access 36 Pages 2018
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling Fulltext Access 36 Pages 2018
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction Fulltext Access 36 Pages 2018
Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents Fulltext Access 36 Pages 2018
Metabolic profiling associated with autophagy of human placenta-derived mesenchymal stem cells by chemical isotope labeling LCâMS Fulltext Access 36 Pages 2018
Synthesis, antileishmanial activity and mechanism of action studies of novel β-carboline-1,3,5-triazine hybrids Fulltext Access 36 Pages 2018
The depressed central carbon and energy metabolisms is associated to the acquisition of levofloxacin resistance in Vibrio alginolyticus Fulltext Access 36 Pages 2018
Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells Fulltext Access 36 Pages 2018
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors Fulltext Access 36 Pages 2018
In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer Fulltext Access 36 Pages 2018
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase Fulltext Access 36 Pages 2018
Discovery and structure-activity relationships study of thieno[2,3-b]pyridine analogues as hepatic gluconeogenesis inhibitors Fulltext Access 36 Pages 2018
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK) Fulltext Access 36 Pages 2018
Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents Fulltext Access 36 Pages 2018
Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring Fulltext Access 36 Pages 2018
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors Fulltext Access 36 Pages 2018
Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases Fulltext Access 36 Pages 2018
Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP85-99) epitope: Towards selective immunosuppression Fulltext Access 36 Pages 2018
Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors Fulltext Access 36 Pages 2018
Anti-biofilm effect of novel thiazole acid analogs against Pseudomonas aeruginosa through IQS pathways Fulltext Access 36 Pages 2018
In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector Fulltext Access 37 Pages 2018
Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma Fulltext Access 37 Pages 2018
Robust high-yield ~1â¯TBq production of cyclotron based sodium [99mTc]pertechnetate Fulltext Access 37 Pages 2018
Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [64Cu]-DOTHA2-PEG-RM26 Fulltext Access 37 Pages 2018
4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion Fulltext Access 37 Pages 2018
Glucocorticoid hormone treatment enhances the cytokine production of regulatory T cells by upregulation of Foxp3 expression Fulltext Access 37 Pages 2018
Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent Fulltext Access 37 Pages 2018
Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production Fulltext Access 37 Pages 2018
GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice Fulltext Access 37 Pages 2018
Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds Fulltext Access 37 Pages 2018
Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis Fulltext Access 37 Pages 2018
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators Fulltext Access 37 Pages 2018
Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities Fulltext Access 37 Pages 2018
Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity Fulltext Access 37 Pages 2018
A multi-omics analysis of the regulatory changes induced by miR-223 in a monocyte/macrophage cell line Fulltext Access 37 Pages 2018
Regio- and stereoselective synthesis of dispirooxindole-pyrrolocarbazole hybrids via 1,3-dipolar cycloaddition reactions: Cytotoxic activity and SAR studies Fulltext Access 37 Pages 2018
Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides Fulltext Access 37 Pages 2018
Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease Fulltext Access 37 Pages 2018
Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis Fulltext Access 37 Pages 2018
MT-ND5 Mutation Exhibits Highly Variable Neurological Manifestations at Low Mutant Load Fulltext Access 37 Pages 2018
Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation Fulltext Access 37 Pages 2018
Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo Fulltext Access 37 Pages 2018
Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis Fulltext Access 37 Pages 2018
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation Fulltext Access 37 Pages 2018
An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation Fulltext Access 37 Pages 2018
Design and synthesis of new hybrids from 2-cyano-3,12-dioxooleana- 9-dien-28-oic acid and O2-(2,4-dinitrophenyl) diazeniumdiolate for intervention of drug-resistant lung cancer Fulltext Access 37 Pages 2018
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor Fulltext Access 37 Pages 2018
Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy Fulltext Access 37 Pages 2018
Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation Fulltext Access 37 Pages 2018
Synthesis and structure-activity relationship of novel bisindole amidines active against MDR Gram-positive and Gram-negative bacteria Fulltext Access 37 Pages 2018
Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold Fulltext Access 37 Pages 2018
New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation Fulltext Access 37 Pages 2018
Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole Fulltext Access 37 Pages 2018
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Fulltext Access 37 Pages 2018
A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy Fulltext Access 37 Pages 2018
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides Fulltext Access 37 Pages 2018
Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling Fulltext Access 37 Pages 2018