IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats Fulltext Access 8 Pages 2008
The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles? Fulltext Access 8 Pages 2008
Physiological relevance of GPCR oligomerization and its impact on drug discovery Fulltext Access 8 Pages 2008
Effect of mergers and acquisitions on drug discovery: perspective from a case study of a Japanese pharmaceutical company Fulltext Access 8 Pages 2008
Case study: impact of technology investment on lead discovery at Bristol–Myers Squibb, 1998–2006 Fulltext Access 8 Pages 2008
Towards improving compound selection in structure-based virtual screening Fulltext Access 8 Pages 2008
Differential sensitivity to cadmium of key mitochondrial enzymes in the eastern oyster, Crassostrea virginica Gmelin (Bivalvia: Ostreidae) Fulltext Access 8 Pages 2008
Effects of Cu2+ and Pb2+ on different fish species: Liver cytochrome P450-dependent monooxygenase activities and FTIR spectra Fulltext Access 8 Pages 2008
Fluorine magnetic resonance in vivo: A powerful tool in the study of drug distribution and metabolism Fulltext Access 8 Pages 2008
Effectiveness of leech therapy in women with symptomatic arthrosis of the first carpometacarpal joint: A randomized controlled trial Fulltext Access 8 Pages 2008
Laser acupuncture in children with headache: A double-blind, randomized, bicenter, placebo-controlled trial Fulltext Access 8 Pages 2008
Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice Fulltext Access 8 Pages 2008
Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury Fulltext Access 8 Pages 2008
Incidence rates and treatment of neuropathic pain conditions in the general population Fulltext Access 8 Pages 2008
Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice Fulltext Access 8 Pages 2008
Increased pain sensitivity is not a risk factor but a consequence of frequent headache: A population-based follow-up study Fulltext Access 8 Pages 2008
Attempting to solve the problem of pain: A questionnaire study in acute and chronic pain patients Fulltext Access 8 Pages 2008
Loose ligation of the sciatic nerve is associated with TrkB receptor-dependent decreases in KCC2 protein levels in the ipsilateral spinal dorsal horn Fulltext Access 8 Pages 2008
Prevalence of chronic pain with neuropathic characteristics in the general population Fulltext Access 8 Pages 2008
Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats Fulltext Access 8 Pages 2008
Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli Fulltext Access 8 Pages 2008
A new type of neuron-specific aminopeptidase NAP-2 in rat brain synaptosomes Fulltext Access 8 Pages 2008
CB2 cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: Role of CB2 receptor in pain Fulltext Access 8 Pages 2008
Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit Fulltext Access 8 Pages 2008
Differential crosstalk between P2X7 and arachidonic acid in activation of mitogen-activated protein kinases Fulltext Access 8 Pages 2008
Flesinoxan challenge suggests that chronic treatment with paroxetine in rats does not desensitize receptors controlling 5-HT synthesis Fulltext Access 8 Pages 2008
Activation of phosphatidylcholine signalling during oxidative stress in synaptic endings Fulltext Access 8 Pages 2008
When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP) Fulltext Access 8 Pages 2008
Stem cell reprogramming: generation of patient-specific stem cells by somatic cell nuclear reprogramming Fulltext Access 8 Pages 2008
The impact of physical based methods screening and their delivery of better quality hits Fulltext Access 8 Pages 2008
Arthritis self-efficacy and self-efficacy for resisting eating: Relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain Fulltext Access 8 Pages 2008
A case study of lean drug discovery: from project driven research to innovation studios and process factories Fulltext Access 8 Pages 2008
Challenges in design of biochemical assays for the identification of small molecules to target multiple conformations of protein kinases Fulltext Access 8 Pages 2008
Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers Fulltext Access 8 Pages 2008
The Chronic Pain Acceptance Questionnaire: Confirmatory factor analysis and identification of patient subgroups Fulltext Access 8 Pages 2008
Virtual human technology: Capturing sex, race, and age influences in individual pain decision policies Fulltext Access 8 Pages 2008
Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression Fulltext Access 8 Pages 2008
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan Fulltext Access 8 Pages 2008
Spinal cord stimulation in severe angina pectoris - A systematic review based on the Swedish Council on Technology assessment in health care report on long-standing pain Fulltext Access 8 Pages 2008
Indications and contraindications for thoracic epidural analgesia in multiply injured patients Fulltext Access 8 Pages 2008
A benchmark of 3 years experiences in acute pain service at Srinagarind hospital Fulltext Access 8 Pages 2008
Management of pain in a surgical emergency unit—Underlying factors affecting its delivery Fulltext Access 8 Pages 2008
In vivo occipital–frontal temperature-gradient in schizophrenia patients and its possible association with psychopathology: A magnetic resonance spectroscopy study Fulltext Access 8 Pages 2008
Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia Fulltext Access 8 Pages 2008
CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD Fulltext Access 8 Pages 2008
Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls Fulltext Access 8 Pages 2008
Norchloro-fluoro-homoepibatidine (NCFHEB) — A promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET Fulltext Access 8 Pages 2008
Management of physical health in schizophrenia: A stepping stone to treatment success Fulltext Access 8 Pages 2008
Relationship between antidepressants and IGF-1 system in the brain: Possible role in cognition Fulltext Access 8 Pages 2008
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and d-serine Fulltext Access 8 Pages 2008
The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: A preliminary study Fulltext Access 8 Pages 2008
Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder Fulltext Access 8 Pages 2008
Pregabalin in patients with central neuropathic pain: A randomized, double-blind, placebo-controlled trial of a flexible-dose regimen Fulltext Access 8 Pages 2008
Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception Fulltext Access 8 Pages 2008
Parental response to children’s pain: The moderating impact of children’s emotional distress on symptoms and disability Fulltext Access 8 Pages 2008
Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy Fulltext Access 8 Pages 2008
Cerebral activation during motor imagery in complex regional pain syndrome type 1 with dystonia Fulltext Access 8 Pages 2008
Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord Fulltext Access 8 Pages 2008
The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level Fulltext Access 8 Pages 2008
The Fear of Pain Questionnaire - Short Form (FPQ-SF): Factorial validity and psychometric properties Fulltext Access 8 Pages 2008
Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons Fulltext Access 8 Pages 2008
The utility of pain assessment for analgesic use in persons with dementia Fulltext Access 8 Pages 2008
Experimentally induced various inflammatory models and seizure: Understanding the role of cytokine in rat Fulltext Access 8 Pages 2008
Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter? Fulltext Access 8 Pages 2008
Abnormal processing of the nociceptive input in Parkinson's disease: A study with CO2 laser evoked potentials Fulltext Access 8 Pages 2008
Population-based cohort study of incident and persistent arm pain: Role of mental health, self-rated health and health beliefs Fulltext Access 8 Pages 2008
Characteristics of chronic ischemic pain in patients with peripheral arterial disease Fulltext Access 8 Pages 2008
Spinal cord stimulation normalizes abnormal cortical pain processing in patients with cardiac syndrome X Fulltext Access 8 Pages 2008
Assessing fear in patients with cervical pain: Development and validation of the Pictorial Fear of Activity Scale-Cervical (PFActS-C) Fulltext Access 8 Pages 2008
Psychological predictors of pain expression and activity intolerance in chronic pain patients Fulltext Access 8 Pages 2008
Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test Fulltext Access 8 Pages 2008
Combined effects of major depression, pain and somatic disorders on general functioning in the general adult population Fulltext Access 8 Pages 2008
Oral opioid use alters DNIC but not cold pain perception in patients with chronic pain - New perspective of opioid-induced hyperalgesia Fulltext Access 8 Pages 2008
The structure, reliability and validity of pain expression: Evidence from patients with shoulder pain Fulltext Access 8 Pages 2008