کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10260696 | 439018 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics](/preview/png/10260696.png)
چکیده انگلیسی
To obtain information on the effects of a divalent cation (Ca2+) on the membrane properties of the lipid A analog, E5531, the particle size, ξ potential, membrane fluidity and pharmacokinetices was investigated in rats after the addition of calcium ion. Within a molar ratio for [Ca2+]/[E5531] ⤠3, the presence of Ca2+ increased the potentials of the E5531 membrane, but had no effect on particle size. Ca2+ decreased membrane fluidity and the pharmacokinetics in rats. These effects of Ca2+ on the membrane properties of E5531 particles could be eliminated by the addition of EDTA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Powder Technology - Volume 16, Issue 4, 2005, Pages 413-418
Journal: Advanced Powder Technology - Volume 16, Issue 4, 2005, Pages 413-418
نویسندگان
Yasuyuki Asai,