Physicochemical properties and antioxidant activity of α-tocopherol loaded nanoliposome’s containing DHA and EPA

• The stable liposome formulation was developed for DHA and EPA.
• α-Tocopherol has significant effect on physicochemical properties of the nanocarriers.
• Appropriate physicochemical properties were obtained during storage at 4 °C.

The aim of this study was to prepare α-tocopherol loaded nanoliposomes as carriers of DHA and EPA and to investigate their physicochemical properties, such as peroxide value (PV), volatile compounds (VOCs), particle size, size distribution, zeta potential and morphology of the liposomes. The particle size of liposomes was in the range of 82.4–107.2 nm. The highest extent of lipid oxidation was observed at 40 °C for 90 days, with the lowest PV and propanal levels for a nanoliposome formulation in comparison with the control sample. The zeta potential of the nanoliposomes was decreased during storage. No significant change in the PV and zeta potential of the liposome formulations with α-tocopherol was observed at 4 °C after 90 days (0.14 meq/kg and −43.5 mV, respectively). This study demonstrated that incorporation of α-tocopherol into liposomes contributes a significant antioxidant effect on DHA and EPA.

Summary of nanoliposome project.Figure optionsDownload as PowerPoint slide