Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity

• Synthesis of series of stable aromatic and heteroaromatic sulfonyl amidoximes.
• Biological evaluation of sulfonyl amidoximes, realized for the first time.
• The majority of compounds exhibited inhibition of free hydroxyl radicals.
• Some exhibited lipid peroxidation activity.

We describe herein the synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes, from the reaction of amidoximes with the corresponding sulfonyl chlorides, in low to excellent yields. Evaluation of their antioxidant activity has shown that 17 out of 28 compounds highly compete DMSO for hydroxyl radicals, while five of them inhibit lipid peroxidation. Combining the reducing and anti-lipid peroxidation ability it seems that compounds 13 and 31 could be used as lead molecules.

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