Solubility of fenamate drugs in supercritical carbon dioxide by using a semi-flow apparatus with a continuous solvent-washing step in the depressurization line

- New solubility data of niflumic and tolfenamic acid in supercritical CO2.
- A continuous solvent-washing step of the depressurization line was adopted.
- Comparison with literature reveals that solubility data underestimation is avoided.
- Data correlation performances of fourteen empirical models were compared.
- Adachi-Lu and del Valle-Aguilera models provided the best data fit.