Supercritical fluid micronization techniques for gastroresistant insulin formulations

- Comparison of GAS, ASES and ARISE processes to produce insulin-HPMCP composites.
- Composites from the GAS and ASES processes have bimodal particle size distribution.
- Particle size increased with higher drug to polymer mass ratio in all processes.
- The ARISE process produced the insulin-HPMCP composite with the highest coating efficiency.