کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
816599 | 1469265 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC.
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of the present study was to investigate and compare the analgesic and anti-inflammatory activities of hydroalcoholic extracts of bark and leaves of Acacia ferruginea DC. Hydroalcoholic extracts of bark and leaves were evaluated for analgesic activity using hot plate method and acetic acid-induced writhing test, whereas the anti-inflammatory activity was evaluated by carrageenan-induced paw oedema method. Hydroalcoholic extract of the bark at the dose of 50âmg/kg (6.10â±â0.30) and leaves at a dose of 100âmg/kg (5.72â±â0.39) after 45âmin exhibited significant (Pâ<â0.001) analgesic activity in hot plate test, which was comparable to Tramadol (6.11â±â0.31) at a dose of 10âmg/kg. However, in acetic acid-induced writhing test, hydroalcoholic extract of both bark (90%) and leaves (90.91%) showed maximum protection from acetic acid at the dose of 100âmg/kg as compared to standard drug (50.91%) at a dose of 5âmg/kg. In the evaluation of anti-inflammatory activity, hydroalcoholic extract of leaves at a dose of 400âmg/kg had significantly (74.68%) inhibited the inflammation as comparable to indomethacin (82.8%) after 3âh of induction of carrageenan. It is concluded that hydroalcoholic extracts of bark and leaves have central analgesic and peripheral analgesic effects, respectively. Both hydroalcoholic extracts of the bark and leaves significantly reduced the paw oedema at a dose of 400âmg/kg and exhibited anti-inflammatory activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Beni-Suef University Journal of Basic and Applied Sciences - Volume 5, Issue 1, March 2016, Pages 70-78
Journal: Beni-Suef University Journal of Basic and Applied Sciences - Volume 5, Issue 1, March 2016, Pages 70-78
نویسندگان
Samriti Faujdar, Swapnil Sharma, Bhawna Sati, A.K. Pathak, Sarvesh Kumar Paliwal,