کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336761 | 1540642 | 2015 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats
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کلمات کلیدی
VIPOPLS-DAPGSHDL-CSAMLDL-CPLS-DAUPLCFASFFAnuclear magnetic resonance - رزونانس مغناطیسی هستهایPCA - PCADyslipidemia - اختلالات چربی خون یا دیسپیدمیS-adenosylmethionine - اس-ادنوزیل متیونینArachidonic acid - اسید آراشیدونیکFree fatty acid - اسید چرب آزادfatty acid synthase - اسید چرب سنتازvariable importance in projection - اهمیت متغیر در طرحPrincipal component analysis - تحلیل مولفههای اصلی یا PCANMR - تشدید مغناطیسی هستهای high-fat diet - رژیم غذایی با چربی بالاOat bran - سبوس جوMass spectrometry - طیف سنجی جرمیphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanolamine - فسفاتیدیلتانولامینhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالMetabolomics - متابولومیکProstaglandins - پروستاگلاندین هاUltra-performance liquid chromatography - کروماتوگرافی مایع فوق العاده عملکردیhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراGas chromatography - کروماتوگرافی گازیtotal cholesterol - کلسترول تامTotal triglyceride - کلسترول تری گلیسریدLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study aimed to explore the metabolic response of oat bran consumption in dyslipidemic rats by a high-throughput metabolomics approach. Four groups of Sprague-Dawley rats were used: N group (normal chow diet), M group (dyslipidemia induced by 4-week high-fat feeding, then normal chow diet), OL group and OH group (dyslipidemia induced, then normal chow diet supplemented with 10.8% or 43.4% naked oat bran). Intervention lasted for 12Â weeks. Gas chromatography quadrupole time-of-flight mass spectrometry was used to identify serum metabolite profiles. Results confirmed the effects of oat bran on improving lipidemic variables and showed distinct metabolomic profiles associated with diet intervention. A number of endogenous molecules were changed by high-fat diet and normalized following supplementation of naked oat bran. Elevated levels of serum unsaturated fatty acids including arachidonic acid (Log2Fold of change=0.70, P=.02 OH vs. M group), palmitoleic acid (Log2Fold of change=1.24, P=.02 OH vs. M group) and oleic acid (Log2Fold of change=0.66, P=.04 OH vs. M group) were detected after oat bran consumption. Furthermore, consumption of oat bran was also characterized by higher levels of methionine and S-adenosylmethionine. Pathway exploration found that most of the discriminant metabolites were involved in fatty acid biosynthesis, biosynthesis and metabolism of amino acids, microbial metabolism in diverse environments and biosynthesis of plant secondary metabolites. These results point to potential biomarkers and underlying benefit of naked oat bran in the context of diet-induced dyslipidemia and offer some insights into the mechanism exploration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 26, Issue 12, December 2015, Pages 1509-1519
Journal: The Journal of Nutritional Biochemistry - Volume 26, Issue 12, December 2015, Pages 1509-1519
نویسندگان
Jiaojiao Gu, Lulu Jing, Xiaotao Ma, Zhaofeng Zhang, Qianying Guo, Yong Li,