Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers
Keywords: رتیکولوم سارکوپلاسمیک; Phospholamban; SERCA2a; Protein kinase A; Sarcoplasmic reticulum;
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Influence of Transgenic Overexpression of Phospholamban on Postextrasystolic Potentiation
Keywords: رتیکولوم سارکوپلاسمیک; Force-interval behavior; Sarcoplasmic reticulum; Ca2+ATPase; Phospholamban.
Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells
Keywords: رتیکولوم سارکوپلاسمیک; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; FKBP; FK506-binding protein; FPP; farnesyl pyrophosphate; GAPDH; glyceraldehyde phosphate dehydrogenase; GGPP; geranylgeranyl pyrophosphate; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A;
Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2
Keywords: رتیکولوم سارکوپلاسمیک; Calsequestrin; Calmodulin; Calcium release restitution; L-type calcium channel; Sarcoplasmic reticulum;
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity
Keywords: رتیکولوم سارکوپلاسمیک; Ï; time constant; Ïwash-in; wash-in time constant; Ïwash-out; wash-out time constant; AIP; autocamtide-2 related inhibitory peptide; Bmax; binding maximum; CaM; calmodulin; CaSpF; calcium spark frequency; DAN; dantrolene; F; fluorescent; FDHM; full dur
Decreased repolarization reserve increases defibrillation threshold by favoring early afterdepolarizations in an in silico model of human ventricular tissue
Keywords: رتیکولوم سارکوپلاسمیک; 2D; 2-dimensional; DFT; defibrillation threshold; EAD; early afterdepolarization; SFa; spiral fibrillation type a; SFb; spiral fibrillation type b; SR; sarcoplasmic reticulum; TdP; torsades de pointes; Early afterdepolarization; Ventricular fibrillation;
Role of L-type Ca2 + channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage
Keywords: رتیکولوم سارکوپلاسمیک; Basilar arterial rings; L-type Ca2 + channels; RhoA/Rho kinase; Sarcoplasmic reticulum; Subarachnoid hemorrhage
Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current
Keywords: رتیکولوم سارکوپلاسمیک; Calcium; Atria; Heart failure; Sarcoplasmic reticulum;
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions
Keywords: رتیکولوم سارکوپلاسمیک; BDVT; bidirectional ventricular tachycardia; CaMKII; calcium/calmodulin-dependent protein kinase II; CPVT; catecholaminergic polymorphic ventricular tachycardia; CSQ; calsequestrin; DAD; delayed afterdepolarization; ECG; electrocardiography; JKO; junctin
Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes
Keywords: رتیکولوم سارکوپلاسمیک; cAMP; 3â²,5â²-cyclic adenosine monophosphate; PKA; protein kinase A; EPAC; Exchange Protein directly Activated by Cyclic AMP; LTCC; L-type Ca2+ channel; NCX; Na+/Ca2+ exchanger; RyR; ryanodine receptor; SR; sarcoplasmic reticulum; TRPC; Transient Recept
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
Keywords: رتیکولوم سارکوپلاسمیک; ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;
Gingerols and shogaols: Important nutraceutical principles from ginger
Keywords: رتیکولوم سارکوپلاسمیک; BSA; bovine serum albumin; COX; cyclooxygenase; GN; gingerol; HepG2; human hepatoma G2; iNOS; inducible NO synthase; LPS; lipopolysaccharide; MBC; minimum bactericidal concentration; MIC; minimal inhibitory concentration; NF-κB; nuclear factor-kappa B; N
Cardioprotective potential of annexin-A1 mimetics in myocardial infarction
Keywords: رتیکولوم سارکوپلاسمیک; Ac2-26; Cardioprotection; Cardiomyopathy; Formyl peptide receptors; Inflammation; Ischemia-reperfusion; Aβ42; 42-amino acid beta-amyloid peptide; ABC; ATP-binding cassette; Ac2-26; N-terminal-derived annexin-A1 peptide (acetyl-AMVSEFLKQAWIENEEQEYVVQTVK
Overexpression of ANO1/TMEM16A, an arterial Ca2Â +-activated Clâ channel, contributes to spontaneous hypertension
Keywords: رتیکولوم سارکوپلاسمیک; Ang II; angiotensin II; BP; blood pressure; CA; carotid artery; CaCC; Ca2Â +-activated Clâ channel or currents; DBP; diastolic blood pressure; EH; essential hypertension; GWAS; genome-wide association studies; HLA; hind limb artery; MA; mesenteric arter
STIM1 elevation in the heart results in aberrant Ca2Â + handling and cardiomyopathy
Keywords: رتیکولوم سارکوپلاسمیک; AngII; angiotensin II; BDM; 2,3-butanedione monoxime; CaMKII; Ca2Â +/calmodulin-dependent protein kinase II; CMF; Ca2Â +- and Mg2Â +-free Ringer's solution; CPA; cyclopiazonic acid; EC; excitation-contraction; ER; endoplasmic reticulum; LTCC; L-type Ca2
Weakness, SR function and stress in gastrocnemius muscles of aged male rats
Keywords: رتیکولوم سارکوپلاسمیک; SR; sarcoplasmic reticulum; ER; endoplasmic reticulum; lo; optimal length; E-C coupling; excitation-contraction coupling; CSA; cross-sectional area; aSMase; acid sphingomyelinase; nSMase; neutral sphingomyelinase; SPT; serine palmitoyltransferase; GP;
Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart
Keywords: رتیکولوم سارکوپلاسمیک; ATF6; Cardiac hypertrophy; Cardiac myocyte; Sarcoplasmic reticulum; Endoplasmic reticulum; Protein quality control;
Cardiovascular pharmacologyEnhanced vasoconstriction to α1-adrenoceptor stimulation during cooling in mouse cutaneous plantar arteries
Keywords: رتیکولوم سارکوپلاسمیک; Cooling-induced vasoconstriction; Arteriography: mouse; Plantar artery; Sarcoplasmic reticulum; Calcium channel;
Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes
Keywords: رتیکولوم سارکوپلاسمیک; Calmodulin; Ryanodine receptor; Sarcoplasmic reticulum; Calcium; CPVT;
SPRC protects hypoxia and re-oxygenation injury by improving rat cardiac contractile function and intracellular calcium handling
Keywords: رتیکولوم سارکوپلاسمیک; H/R; hypoxia and re-oxygenation; SR; sarcoplasmic reticulum; RyR; ryanodine receptor; SERCA; Ca2+ATPase; ECC; excitation-contraction coupling; MDA; malondialdehyde; SOD; superoxide dismutase; GSH; glutathione; CSE; cystathionine-γ-lyase; Ca2+; Hypoxia
Nitric oxide improves the hemodynamic performance of the hypoxic goldfish (Carassius auratus) heart
Keywords: رتیکولوم سارکوپلاسمیک; NOS; nitric oxide synthase; NO; nitric oxide; SV; stroke volume; sGC; soluble guanylyl cyclase; HIF-1α; hypoxia inducible factor α; Hb; hemoglobin; CO; cardiac output; HR; heart rate; SW; stroke work; L-NMMA; NG-monomethyl-L-arginine; GSNO; S-nitrosoglu
Mechanistic basis of excitation-contraction coupling in human pluripotent stem cell-derived ventricular cardiomyocytes revealed by Ca2+ spark characteristics: Direct evidence of functional Ca2+-induced Ca2+ release
Keywords: رتیکولوم سارکوپلاسمیک; AP; action potential; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CICR; Ca2+-induced Ca2+ release; CM; cardiomyocyte; EC; excitation-contraction; FDHM; full duration at half maximum; FWHM; full width at half maximum; hESC; human embryonic stem cell;
Tributyltin contributes in reducing the vascular reactivity to phenylephrine in isolated aortic rings from female rats
Keywords: رتیکولوم سارکوپلاسمیک; l-NAME; NG-Nitro-l-Arginine Methyl Ester; TBT; tributyltin; PHE; phenylephrine; ACh; acetylcholine; SNP; sodium nitroprusside; CONT; Control; NO; nitric oxide; TEA; tetraethylammonium; SR; sarcoplasmic reticulum; OTCs; Organotin compounds; ROS; reactive o
A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2Â + transients and contractile function in cardiomyocytes
Keywords: رتیکولوم سارکوپلاسمیک; SR; sarcoplasmic reticulum; SERCA2a; sarco(endo)plasmic reticulum Ca2Â +-ATPase 2a; PLN; phospholamban; PKA; cAMP-dependent protein kinase; SELEX; systematic evolution of ligands by exponential enrichment; Aptamer; Calcium signaling; Cardiac sarcoplasmic
An integrated mechanism of cardiomyocyte nuclear Ca2Â + signaling
Keywords: رتیکولوم سارکوپلاسمیک; Ang II; angiotensin II; E-C; excitation-contraction; ER; endoplasmic reticulum; ET-1; endothelin-1; IGF-1; insulin-like growth factor-1; INM; inner nuclear membrane; InsP3; inositol 1,4,5-trisphosphate; InsP3R; InsP3 receptor; NE; nuclear envelope; ON
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
Keywords: رتیکولوم سارکوپلاسمیک; [Ca2 +]; free Ca2 + concentration; DTT; dithiothreitol; EGTA; ethyleneglycol-bis(β-aminoethyl ether) N, N, Nâ², Nâ²-tetraacetic acid; ER; endoplasmic reticulum; GSH; glutathione; HEDTA; N-(2-hydroxyethyl)-ethylenediamine-triacetic acid; I5R1; 5 min
Crystal structure of phospholipase PA2-Vb, a protease-activated receptor agonist from the Trimeresurus stejnegeri snake venom
Keywords: رتیکولوم سارکوپلاسمیک; PLA2; phospholipases A2; PAR-1; protease-activated receptor 1; IP3R; inositol 1,4,5-trisphosphate receptor; svPLA2; snake venom PLA2; VSMCs; vascular smooth muscle cells; SR; sarcoplasmic reticulum; RyR; ryanodine receptor; GPCRs; G-protein coupled recept
How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity
Keywords: رتیکولوم سارکوپلاسمیک; APD; action potential duration; EAD; early afterdepolarization; ICa,L; L-type Ca2+ current; IK1; inward rectifier K+ current; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; KCNE1; β-subunit to KvLQT1 to form slow delayed
NAD derived second messengers: Role in spontaneous diastolic Ca2+ transients in murine cardiac myocytes
Keywords: رتیکولوم سارکوپلاسمیک; ADPRC; ADP-ribosyl cyclase; [Ca2+]i; free cytososlic Ca2+ concentration; [Ca2+]SR; free sarcoplasmic reticular-luminal Ca2+ concentration; Iso; isoproterenol; NAADP; nicotinic acid adenine dinucleotide phosphate; RyR; ryanodine receptor; SCT; spontaneous
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII
Keywords: رتیکولوم سارکوپلاسمیک; NOX2; NADPH oxidase 2; gp91phox; catalytic subunit of NOX2; Ang II; Angiotensin II; ROS; Reactive oxygen species; H89; N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide; SERCA; SR Ca ATPAse; SR; sarcoplasmic reticulum; AIP; autoca
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury
Keywords: رتیکولوم سارکوپلاسمیک; AC3-I; Ca2+-calmodulin kinase II-inhibitory peptide; Ca2+; Calcium; CaMKII; Ca2+-calmodulin kinase II; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; I/R; Ischemia/reperfusion; LAD; Left anterior descending; LDH; Lactodehydrogenase; MI; Myocardial infar
Ca2Â + homeostasis in sealed t-tubules of mouse ventricular myocytes
Keywords: رتیکولوم سارکوپلاسمیک; [Ca2Â +]in; intracellular [Ca2Â +]; [Ca2Â +]o; extracellular [Ca2Â +]; [Ca2Â +]st; [Ca2Â +] in sealed t-tubules; Ko; extracellular K+; SR; sarcoplasmic reticulum; NCX; sodium/calcium exchanger; Ventricular myocytes; T-tubules; Hyposmotic stress; Calcium;
cAMP signaling in subcellular compartments
Keywords: رتیکولوم سارکوپلاسمیک; cAMP; Compartmentalization; PKA; PDEs; AKAPs; Signaling; cAMP; 3â²-5â²-cyclic adenosine monophosphate; GPCRs; G-protein coupled receptors; EPAC; Guanine-nucleotide exchange proteins activated by cAMP; PKA; cAMP-dependent protein kinase; PDEs; Phosphod
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay
Keywords: رتیکولوم سارکوپلاسمیک; ANT; adenine nucleotide translocase; CsA; cyclosporin A; Cyp-D; cyclophillin D; IR; ischaemia and reperfusion; Lmax; length at which maximum developed force was recorded; Lopt; 95% of Lmax; LWa; work required to lengthen the active muscle; LWp; work requi
The potassium channel opener NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA
Keywords: رتیکولوم سارکوپلاسمیک; BKCa channel; large conductance Ca2+-activated K+ channel; NS1619; 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazole-2-one; SR; sarcoplasmic reticulum; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; CGS7184; (ethyl
EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development
Keywords: رتیکولوم سارکوپلاسمیک; CSA; cross sectional area; T-tubule; transverse tubule; SR; sarcoplasmic reticulum; EHD; Eps15 homology domain; EHD proteins; Fer1L5; T-tubule; Myoblast fusion; Muscle growth;
Sex differences in SR Ca2Â + release in murine ventricular myocytes are regulated by the cAMP/PKA pathway
Keywords: رتیکولوم سارکوپلاسمیک; cAMP; cyclic adenosine monophosphate; DMSO; dimethyl sulfoxide; EC; excitation-contraction; Fura-2 AM; fura-2 acetoxymethyl; FR; fractional release; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; IV; current-voltage; PCR; polymerase chain reaction;
High-mobility group box 1 (HMGB1) impaired cardiac excitation-contraction coupling by enhancing the sarcoplasmic reticulum (SR) Ca2Â + leak through TLR4-ROS signaling in cardiomyocytes
Keywords: رتیکولوم سارکوپلاسمیک; HMGB1; high-mobility group box 1; MI; myocardial infarction; HF; heart failure; RyR; ryanodine receptor; EC; excitation-contraction coupling; SR; sarcoplasmic reticulum; CICR; Ca2Â +-induced Ca2Â + release; ROS; reactive oxygen species; TLR4; Toll-like
Diversity of mitochondrial Ca2+ signaling in rat neonatal cardiomyocytes: Evidence from a genetically directed Ca2+ probe, mitycam-E31Q
Keywords: رتیکولوم سارکوپلاسمیک; CICR; Ca2+-induced Ca2+ release; SR; sarcoplasmic reticulum; EC; excitation contraction; OMM; outer mitochondrial membrane; ROI; region of interest; Calcium (Ca2+); Mitochondria; Calcium (Ca2+) imaging; Cardiomyocyte;
Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells
Keywords: رتیکولوم سارکوپلاسمیک; SGF; flavonoids of Smilax glabra; ANP; atrial natriuretic peptide; SR; sarcoplasmic reticulum; ER; endoplasmic reticulum; IP3; inositol trisphosphate; IP3R; inositol trisphosphate receptor; RyR; ryanodine receptor; RyR2; ryanodine receptor 2; CICR; Ca2+-i
Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure
Keywords: رتیکولوم سارکوپلاسمیک; EC; excitation-contraction; RGK; Rad-Rem-Rem2-Gem/Kir protein; RyR2; type 2 ryanodine-sensitive intracellular Ca2+ release channel; SR; sarcoplasmic reticulum; Rad; RGK protein; CaV1.2; CaV1.3; L-type; Heart failure;
Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle
Keywords: رتیکولوم سارکوپلاسمیک; Excitation/contraction coupling; Sparks; Sarcoplasmic reticulum; Ryanodine receptor;
Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes
Keywords: رتیکولوم سارکوپلاسمیک; ATF; activating transcription factor; Ad-calu; adenovirus containing mouse calumenin 1 cDNA; Ad-lacZ; adenovirus containing lacZ gene; CHOP; C/EBP-homologous protein; ERAD; ER-associated degradation; eIF2; eukaryotic initiation factor 2; ERp57; the thiol
Na/Ca exchange and contraction of the heart
Keywords: رتیکولوم سارکوپلاسمیک; NCX; sodium calcium exchanger; KO; NCX knockout mouse; Ca; calcium; AP; action potential; EC; excitation-contraction coupling; RyRs; ryanodine receptor; SR; sarcoplasmic reticulum; LCCs; L-type Ca channels; Sodium calcium exchanger; Calcium; Heart contr
Sarcoplasmic reticulum Ca2+ refilling is determined by L-type Ca2+ and store operated Ca2+ channels in guinea pig airway smooth muscle
Keywords: رتیکولوم سارکوپلاسمیک; Airway smooth muscle; Sarcoplasmic reticulum; SERCA; Store operated Ca2+ channels; L-type Ca2+ channels;
H+-activated Na+ influx in the ventricular myocyte couples Ca2Â +-signalling to intracellular pH
Keywords: رتیکولوم سارکوپلاسمیک; pHi; intracellular pH; pH transporters; pH regulatory proteins; NHE; Na+/H+ exchange; NBC; Na+-HCO3â co-transport; NCX; Na+/Ca2Â + exchange; SR; sarcoplasmic reticulum; SERCA; sarcoplasmic reticular Ca2Â + ATPase; PMCA; plasmalemmal Ca2Â + ATPase; LTCC;
Inhibition of Na+ channels ameliorates arrhythmias in a drug-induced model of Andersen-Tawil syndrome
Keywords: رتیکولوم سارکوپلاسمیک; APD; action potential duration; ATS1; Andersen-Tawil syndrome; CaA; Ca2+ transient amplitude; CaD; diastolic Ca2+; CV; conduction velocity; CVL; longitudinal conduction velocity; CVT; transverse conduction velocity; DI-ATS1; drug-induced Andersen-Tawil sy
CaV1.2 signaling complexes in the heart
Keywords: رتیکولوم سارکوپلاسمیک; LTCC; L-type Ca2 + channel; βAR; β-adrenergic receptor; EPR; E type prostaglandin receptor; RyR2; type 2 ryanodine receptor; AC; adenylyl cyclase; PDE; phosphodiesterase; PP; protein phosphatase; AKAP; A kinase anchoring protein; PKA; protein kinase A;
Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy
Keywords: رتیکولوم سارکوپلاسمیک; ADPKD; autosomal dominant polycystic kidney disease; APD; action potential duration; AV; atrioventricular; bpm; beats per minute; dpf; days post fertilization; CICR; calcium-induced calcium release; ER; endoplasmic reticulum; hpf; hours post fertilization
While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice
Keywords: رتیکولوم سارکوپلاسمیک; CaMKII; Ca2 +/calmodulin-dependent protein kinase II; ECC; excitation-contraction coupling; FDAR; frequency-dependent acceleration of relaxation; I-1; phosphatase-1 inhibitor-1; Iso; isoproterenol; KO; CaMKIIδ-KO; NCX; Na+/Ca2 +-exchanger; NT; normal