Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats Fulltext Access 28 Pages 2018
Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes Fulltext Access 28 Pages 2018
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion Fulltext Access 28 Pages 2018
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease Fulltext Access 28 Pages 2018
Neuroprotective effects of isosteviol sodium through increasing CYLD by the downregulation of miRNA-181b Fulltext Access 28 Pages 2018
Locomotor activity, emotionality, sensori-motor gating, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease Fulltext Access 28 Pages 2018
The antidepressant effects of É-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway Fulltext Access 28 Pages 2018
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway Fulltext Access 28 Pages 2018
G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions Fulltext Access 28 Pages 2018
Astrocytes and presynaptic plasticity in the striatum: Evidence and unanswered questions Fulltext Access 28 Pages 2018
Raloxifene, a promising estrogen replacement, limits TDP-25 cell death by enhancing autophagy and suppressing apoptosis Fulltext Access 28 Pages 2018
Birthdate-dependent heterogeneity of oculomotor neurons is involved in transmedian migration in the developing mouse midbrain Fulltext Access 28 Pages 2018
Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway Fulltext Access 28 Pages 2018
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway Fulltext Access 28 Pages 2018
Clinical and prognostic features of ALS/MND in different phenotypes-data from a hospital-based registry Fulltext Access 28 Pages 2018
Long term follow-up study of non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson's disease (PD). Strong age-dependency in the effect of NBS Fulltext Access 28 Pages 2018
Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37 Fulltext Access 28 Pages 2018
The ventromedial hypothalamic nucleus plays an important role in anxiolytic-like effect of neuropeptide S Fulltext Access 28 Pages 2018
A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs Fulltext Access 28 Pages 2018
Protective effects of IFN-γ on the kidney of type- 2 diabetic KKAy mice Fulltext Access 28 Pages 2018
Peptide YY (3-36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons Fulltext Access 28 Pages 2018
Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure Fulltext Access 28 Pages 2018
Chitosan (CMD)-mediated co-delivery of SN38 and Snail-specific siRNA as a useful anticancer approach against prostate cancer Fulltext Access 28 Pages 2018
Hypoxia regulates the level of glutamic acid decarboxylase enzymes and interrupts inhibitory synapse stability in primary cultured neurons Fulltext Access 28 Pages 2018
Îlpha1B-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium Fulltext Access 28 Pages 2018
Effects of gem-dihydroperoxides against mutant copperâzinc superoxide dismutase-mediated neurotoxicity Fulltext Access 29 Pages 2018
ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats Fulltext Access 29 Pages 2018
Pirouetting pigs: A large non-primate animal model based on unilateral 6-hydroxydopamine lesioning of the nigrostriatal pathway Fulltext Access 29 Pages 2018
Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells Fulltext Access 29 Pages 2018
Deficits in temporal order memory induced by interferon-alpha (IFN-α) treatment are rescued by aerobic exercise Fulltext Access 29 Pages 2018
AMN082-a metabotropic glutamate receptor type 7 allosteric agonist in the NAc facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats Fulltext Access 29 Pages 2018
Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries Fulltext Access 29 Pages 2018
The effect of intrathecal injection of irisin on pain threshold and expression rate of GABAB receptors in peripheral neuropathic pain model Fulltext Access 29 Pages 2018
Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain Fulltext Access 29 Pages 2018
Intraperitoneal injection of nesfatin-1 primarily through the CCK-CCK1R signal pathway affects expression of appetite factors to inhibit the food intake of Siberian sturgeon (Acipenser baerii) Fulltext Access 29 Pages 2018
Reduced retromer function results in the accumulation of amyloid-beta oligomers Fulltext Access 29 Pages 2018
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis Fulltext Access 29 Pages 2018
Response of NPY immunoreactivity in the tadpole brain exposed to energy rich and energy depleted states Fulltext Access 29 Pages 2018
TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation Fulltext Access 29 Pages 2018
IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways Fulltext Access 29 Pages 2018
Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference Fulltext Access 29 Pages 2018
MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokine CCL8 in the spinal cord in a mouse model of colitis Fulltext Access 29 Pages 2018
Uranium exposure of human dopaminergic cells results in low cytotoxicity, accumulation within sub-cytoplasmic regions, and down regulation of MAO-B Fulltext Access 29 Pages 2018
Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor Fulltext Access 29 Pages 2018
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration Fulltext Access 29 Pages 2018
Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8 Fulltext Access 29 Pages 2018
Normative distribution of substance P and its tachykinin neurokinin-1 receptor in the medullary serotonergic network of the human infant during postnatal development Fulltext Access 29 Pages 2018
Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment Fulltext Access 29 Pages 2018
Ca2+-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels Fulltext Access 29 Pages 2018
Effect of co-administration of two different phosphodiesterase inhibitors and a β3-adrenoceptor agonist in an experimental model of detrusor overactivity Fulltext Access 29 Pages 2018
Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node Fulltext Access 29 Pages 2018
Morroniside prevents H2O2 or Aβ1-42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation Fulltext Access 29 Pages 2018
Paeonol regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling Fulltext Access 29 Pages 2018
Lost in translation: What's in an EC50? Innovative PK/PD reasoning in the drug development context Fulltext Access 29 Pages 2018
Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake Fulltext Access 29 Pages 2018
Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model Fulltext Access 29 Pages 2018
Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice Fulltext Access 29 Pages 2018
Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites - Neuroimaging results from the WELDOX II study Fulltext Access 29 Pages 2018
Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na+/Ca2+ exchanger expression after transverse abdominal aortic constriction in rats Fulltext Access 29 Pages 2018
Combination of CYP2C19 genotype with non-genetic factors evoking phenoconversion improves phenotype prediction Fulltext Access 29 Pages 2018
The role of nitric oxide-cGMP pathway in selegiline antidepressant-like effect in the mice forced swim test Fulltext Access 29 Pages 2018
Liver carbohydrates metabolism: A new islet-neogenesis associated protein peptide (INGAP-PP) target Fulltext Access 29 Pages 2018
A previously undescribed hexapeptide His-Arg-Phe-Leu-Arg-His-NH2 from amphibian skin secretion shows CO2 and metal biding affinities Fulltext Access 29 Pages 2018
Oxytocin effects on the inhibition of the NF-κB/miR195 pathway in mice breast cancer Fulltext Access 29 Pages 2018
Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain Fulltext Access 29 Pages 2018
Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone Fulltext Access 29 Pages 2018
Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart Fulltext Access 29 Pages 2018
Targeting of EGFR increase anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform Fulltext Access 29 Pages 2018
Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia Fulltext Access 29 Pages 2018
Unusual modes of action of the repellent DEET in insects highlight some human side effects Fulltext Access 29 Pages 2018
Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms Fulltext Access 29 Pages 2018
CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia Fulltext Access 29 Pages 2018
Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress Fulltext Access 29 Pages 2018
Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis Fulltext Access 30 Pages 2018
Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK Fulltext Access 30 Pages 2018
Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells Fulltext Access 30 Pages 2018
Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3 Fulltext Access 30 Pages 2018
L-tryptophan administration and increase in cerebral serotonin levels: Systematic review Fulltext Access 30 Pages 2018
Spatiotemporal expression pattern of Connexin 43 during early chick embryogenesis Fulltext Access 30 Pages 2018
The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5 Fulltext Access 30 Pages 2018
Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway Fulltext Access 30 Pages 2018
Bevacizumab with dose-dense paclitaxel/carboplatin as first-line chemotherapy for advanced ovarian cancer Fulltext Access 30 Pages 2018
Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway Fulltext Access 30 Pages 2018
Secretoneurin suppresses cardiac hypertrophy through suppression of oxidant stress Fulltext Access 30 Pages 2018
Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling Fulltext Access 30 Pages 2018
Glucagon-like Peptide-1 (GLP-1) and neurotransmitters signaling in epilepsy: An insight review Fulltext Access 30 Pages 2018
Prostaglandin D2 evokes potent uterine contraction via the F prostanoid receptor in postpartum rats Fulltext Access 30 Pages 2018
Pre-clinical pharmacodynamic study of a novel oral factor Xa inhibitor zifaxaban Fulltext Access 30 Pages 2018
Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast HTR-8/SVneo cell line Fulltext Access 30 Pages 2018
Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy Fulltext Access 30 Pages 2018
Quaternary ammonium salt of U50,488H elicits protective effects against hypoxic pulmonary hypertension Fulltext Access 30 Pages 2018
The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK Fulltext Access 30 Pages 2018