7α,11β-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties Fulltext Access 4 Pages 2005
Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine Fulltext Access 4 Pages 2005
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14 Fulltext Access 4 Pages 2005
Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H37Rv Fulltext Access 4 Pages 2005
Structure-activity relationships of the oxindole growth hormone secretagogues Fulltext Access 4 Pages 2005
Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation, heterocyclic-fused area and side chains Fulltext Access 4 Pages 2005
N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Fulltext Access 4 Pages 2005
Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists Fulltext Access 4 Pages 2005
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors Fulltext Access 4 Pages 2005
Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities Fulltext Access 4 Pages 2005
Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists Fulltext Access 4 Pages 2005
Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists Fulltext Access 4 Pages 2005
Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression Fulltext Access 4 Pages 2005
Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action Fulltext Access 4 Pages 2005
Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic β-cells Fulltext Access 4 Pages 2005
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide Fulltext Access 4 Pages 2005
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold Fulltext Access 4 Pages 2005
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA Fulltext Access 4 Pages 2005
Synthesis of half-mustard combi-molecules with fluorescence properties: correlation with EGFR status Fulltext Access 4 Pages 2005
Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I Fulltext Access 4 Pages 2005
Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide Fulltext Access 4 Pages 2005
Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification Fulltext Access 4 Pages 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates Fulltext Access 4 Pages 2005
Nonpeptide αvβ3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics Fulltext Access 4 Pages 2005
3-(2,5-Dihydro-1H-pyrrol-2-ylmethoxy)pyridines: synthesis and analgesic activity Fulltext Access 4 Pages 2005
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells Fulltext Access 4 Pages 2005
Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation Fulltext Access 4 Pages 2005
The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide Fulltext Access 4 Pages 2005
Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin Fulltext Access 4 Pages 2005
Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol Fulltext Access 4 Pages 2005
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region Fulltext Access 4 Pages 2005
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) Fulltext Access 4 Pages 2005
Synthesis of isonicotinic acid Nâ²-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents Fulltext Access 4 Pages 2005
Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies Fulltext Access 4 Pages 2005
3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis Fulltext Access 4 Pages 2005
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture Fulltext Access 4 Pages 2005
Antitubercular agents. Part 1: Synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents Fulltext Access 4 Pages 2005
Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors Fulltext Access 4 Pages 2005
Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents Fulltext Access 4 Pages 2005
Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2 Fulltext Access 4 Pages 2005
Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists Fulltext Access 4 Pages 2005
Structure of dimeric ATP synthase from mitochondria: An angular association of monomers induces the strong curvature of the inner membrane Fulltext Access 4 Pages 2005
Localization of the nuclear receptor CAR at the cell membrane of mouse liver Fulltext Access 4 Pages 2005
Quercetin appears in the lymph of unanesthetized rats as its phase II metabolites after administered into the stomach Fulltext Access 4 Pages 2005
A 5′ intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population Fulltext Access 4 Pages 2005
Kinetics of inclusion body formation studied in intact cells by FT-IR spectroscopy Fulltext Access 4 Pages 2005
Prediction of protein secondary structure based on residue pair types and conformational states using dynamic programming algorithm Fulltext Access 4 Pages 2005
Up-regulation of lactosylceramide synthase in MDR1 overexpressing human liver tumour cells Fulltext Access 4 Pages 2005
Binding analysis of a psychrotrophic FKBP22 to a folding intermediate of protein using surface plasmon resonance Fulltext Access 4 Pages 2005
Functional overexpression and in vitro re-association of OpuA, an osmotically regulated ABC-transport complex from Bacillus subtilis Fulltext Access 4 Pages 2005
Expression of macrophage-selective markers in human and rodent adipocytes Fulltext Access 4 Pages 2005
RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis Fulltext Access 4 Pages 2005
How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site? Fulltext Access 4 Pages 2005
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases Fulltext Access 4 Pages 2005
Induction of 15-lipoxygenase-1 impairs expression of HIV-1 receptors CD4 and CXCR4 in monocytic cells Fulltext Access 4 Pages 2005
Respiratory cytochrome c oxidase can be efficiently reduced by the photosynthetic redox proteins cytochrome c6 and plastocyanin in cyanobacteria Fulltext Access 4 Pages 2005
The secondary electron acceptor of photosystem I in Gloeobacter violaceus PCC 7421 is menaquinone-4 that is synthesized by a unique but unknown pathway Fulltext Access 4 Pages 2005
Protective role for cytosolic phospholipase A2α in autoimmune diabetes of mice Fulltext Access 4 Pages 2005
Molecular interaction of δ-conotoxins with voltage-gated sodium channels Fulltext Access 4 Pages 2005
Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives Fulltext Access 4 Pages 2005
Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors Fulltext Access 4 Pages 2005
Detection and control of aspartimide formation in the synthesis of cyclic peptides Fulltext Access 4 Pages 2005
Tryptamine-based human β3-adrenergic receptor agonists. Part 3: Improved oral bioavailability via modification of the sulfonamide moiety Fulltext Access 4 Pages 2005
Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata Fulltext Access 4 Pages 2005
Synthesis and pharmacological evaluation of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione derivatives as potent euglycemic and hypolipidemic agents Fulltext Access 4 Pages 2005
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities Fulltext Access 4 Pages 2005
Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro Fulltext Access 4 Pages 2005
Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate Fulltext Access 4 Pages 2005
Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor Fulltext Access 4 Pages 2005
Chemoenzymatic synthesis of CD52 glycoproteins carrying native N-glycans Fulltext Access 4 Pages 2005
The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene Fulltext Access 4 Pages 2005
Mutations in the “lid” region affect chain length specificity and thermostability of a Pseudomonas fragi lipase Fulltext Access 4 Pages 2005
The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin Fulltext Access 4 Pages 2005
Gene expression and characterization of two 2-oxoacid:ferredoxin oxidoreductases from Aeropyrum pernix K1 Fulltext Access 4 Pages 2005
Significant species-dependence of P700 redox potential as verified by spectroelectrochemistry: Comparison of spinach and Theromosynechococcus elongatus Fulltext Access 4 Pages 2005
Enhancement and inhibition of DNA transcriptional activity by spermine: A marked difference between linear and circular templates Fulltext Access 4 Pages 2005
RNA interference induced by siRNAs modified with 4′-thioribonucleosides in cultured mammalian cells Fulltext Access 4 Pages 2005
Ammonia displaces methanol bound to the water oxidizing complex of photosystem II in the S2 state Fulltext Access 4 Pages 2005
Catalytic residues and substrate specificity of scytalidoglutamic peptidase, the first member of the eqolisin in family (G1) of peptidases Fulltext Access 4 Pages 2005