(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators Fulltext Access 4 Pages 2005
The biosynthetic routes for carbon monoxide and cyanide in the Ni-Fe active site of hydrogenases are different Fulltext Access 4 Pages 2005
Mice transgenic for Alzheimer disease β-amyloid develop lens cataracts that are rescued by antioxidant treatment Fulltext Access 4 Pages 2005
President's Welcome, Table of Contents, Meeting Format, and Plenary Session Topics Fulltext Access 4 Pages 2005
Theoretical and experimental investigation of the relationship among SAR, tissues and radio frequencies in MRI Fulltext Access 4 Pages 2005
Exploring the minimal functional unit of the transporter associated with antigen processing Fulltext Access 4 Pages 2005
Gymnemic acids inhibit rabbit glyceraldehyde-3-phosphate dehydrogenase and induce a smearing of its electrophoretic band and dephosphorylation Fulltext Access 4 Pages 2005
Adenosine diphosphate moiety does not participate in structural changes for the signaling state in the sensor of blue-light using FAD domain of AppA Fulltext Access 4 Pages 2005
Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy- and ribo purinenucleosides using active esters Fulltext Access 4 Pages 2005
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists Fulltext Access 4 Pages 2005
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides Fulltext Access 4 Pages 2005
Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells Fulltext Access 4 Pages 2005
Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain Fulltext Access 4 Pages 2005
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2 Fulltext Access 4 Pages 2005
Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents Fulltext Access 4 Pages 2005
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol Fulltext Access 4 Pages 2005
Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye Fulltext Access 4 Pages 2005
Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid Fulltext Access 4 Pages 2005
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents Fulltext Access 4 Pages 2005
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides Fulltext Access 4 Pages 2005
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines Fulltext Access 4 Pages 2005
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin Fulltext Access 4 Pages 2005
Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide Fulltext Access 4 Pages 2005
Expression of SERCA2a is not regulated by calcineurin or upon mechanical unloading in skeletal muscle regeneration Fulltext Access 4 Pages 2005
The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer Fulltext Access 4 Pages 2005
On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit Fulltext Access 4 Pages 2005
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions Fulltext Access 4 Pages 2005
Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes Fulltext Access 4 Pages 2005
No evidence for a forced-unfolding mechanism during ATP/GroES binding to substrate-bound GroEL: no observable protection of metastable Rubisco intermediate or GroEL-bound Rubisco from tritium exchange Fulltext Access 4 Pages 2005
Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line Fulltext Access 4 Pages 2005
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation Fulltext Access 4 Pages 2005
The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella Fulltext Access 4 Pages 2005
The conserved histidine 106 of large thioredoxin reductases is likely to have a structural role but not a base catalyst function Fulltext Access 4 Pages 2005
Extracellular copper ions regulate cellular prion protein (PrPC) expression and metabolism in neuronal cells Fulltext Access 4 Pages 2005
Heparin recovers AT1 receptor and its intracellular signal transduction in cultured vascular smooth muscle cells Fulltext Access 4 Pages 2005
The reconstitution of unfolded myoglobin with hemin dicyanide is not accelerated by fly-casting Fulltext Access 4 Pages 2005
Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10 Fulltext Access 4 Pages 2005
shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts Fulltext Access 4 Pages 2005
Short and highly efficient synthetic promoters for melanoma-specific gene expression Fulltext Access 4 Pages 2005
Direct interaction of coenzyme M with the active-site Fe-S cluster of heterodisulfide reductase Fulltext Access 4 Pages 2005
Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells Fulltext Access 4 Pages 2005
Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives Fulltext Access 4 Pages 2005
Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A Fulltext Access 4 Pages 2005
Discovery and synthesis of a novel and selective drug-like P2X1 antagonist Fulltext Access 4 Pages 2005
Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents Fulltext Access 4 Pages 2005
Metabolism investigation leading to novel drug design: Orally active prostacyclin mimetics. Part 4 Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro Fulltext Access 4 Pages 2005
6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand Fulltext Access 4 Pages 2005
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives Fulltext Access 4 Pages 2005
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists Fulltext Access 4 Pages 2005
Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists Fulltext Access 4 Pages 2005
Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists Fulltext Access 4 Pages 2005
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia Fulltext Access 4 Pages 2005
A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor Fulltext Access 4 Pages 2005
Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy Fulltext Access 4 Pages 2005
New series of potent δ-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif Fulltext Access 4 Pages 2005
Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases Fulltext Access 4 Pages 2005
A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water Fulltext Access 4 Pages 2005
Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods Fulltext Access 4 Pages 2005
Utilizing the intramolecular Fukuyama–Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity Fulltext Access 4 Pages 2005
SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: A novel class of cytotoxic agents for prostate cancer Fulltext Access 4 Pages 2005
O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity Fulltext Access 4 Pages 2005
Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA Fulltext Access 4 Pages 2005
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists Fulltext Access 4 Pages 2005
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism Fulltext Access 4 Pages 2005
Synthesis, in vivo and in vitro biological activity of novel azaline B analogs Fulltext Access 4 Pages 2005
Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors Fulltext Access 4 Pages 2005
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13 Fulltext Access 4 Pages 2005
A micromethod for the stereochemical analysis of fatty acid desaturase-mediated sulfoxidation reactions Fulltext Access 4 Pages 2005
The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents Fulltext Access 4 Pages 2005
Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants Fulltext Access 4 Pages 2005
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase Fulltext Access 4 Pages 2005