4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents Fulltext Access 4 Pages 2005
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains Fulltext Access 4 Pages 2005
Synthesis of substituted indole derivatives as a new class of antimalarial agents Fulltext Access 4 Pages 2005
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists Fulltext Access 4 Pages 2005
Synthesis and characterization of the monomer ruthenium complex of hypocrellin B Fulltext Access 4 Pages 2005
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists Fulltext Access 4 Pages 2005
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives Fulltext Access 4 Pages 2005
Three-dimensional structure of Plasmodium falciparum Ca2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6 Fulltext Access 4 Pages 2005
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects Fulltext Access 4 Pages 2005
Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids Fulltext Access 4 Pages 2005
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme Fulltext Access 4 Pages 2005
Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II Fulltext Access 4 Pages 2005
DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives Fulltext Access 4 Pages 2005
Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors Fulltext Access 4 Pages 2005
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor Fulltext Access 4 Pages 2005
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Fulltext Access 4 Pages 2005
Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists Fulltext Access 4 Pages 2005
Molecular design, chemical synthesis, and evaluation of cytosine–carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA Fulltext Access 4 Pages 2005
Réchauffement des hypothermies accidentelles majeures par circulation extracorporelle Fulltext Access 4 Pages 2005
Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives Fulltext Access 4 Pages 2005
An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution Fulltext Access 4 Pages 2005
Proposition d'une «bonne pratique opérationnelle: prévention des risques pour le personnel au service biomédical Fulltext Access 4 Pages 2005
A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin Fulltext Access 4 Pages 2005
Méthodologie d'appel d'offres pour les ventilateurs artificiels : questionnaire attaché au Cahier des Clauses Techniques Particulières d'un appel d'offres comme outil d'évaluation et descriptif contractuel d'un ventilateur artificiel Fulltext Access 4 Pages 2005
Ventilation artificielle : quels défis technologiques et quels enjeux pour les industriels ? Fulltext Access 4 Pages 2005
Contrôle de la ventilation sous ventilation mécanique, interaction homme-ventilateur Fulltext Access 4 Pages 2005
Guide des bonnes pratiques biomédicales en établissement de santé : retours d'expérience 2004 Fulltext Access 4 Pages 2005
Proposition d'une bonne pratique en coopération internationale biomédicale Fulltext Access 4 Pages 2005
N-[(3S)-1-Benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human dopamine D4 ligands with high affinity for the 5-HT2A receptor Fulltext Access 4 Pages 2005
Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Fulltext Access 4 Pages 2005
High affinity ligands for the α7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor Fulltext Access 4 Pages 2005
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors Fulltext Access 4 Pages 2005
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography Fulltext Access 4 Pages 2005
Inhibitors of the serotonin transporter protein (SERT): The design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots Fulltext Access 4 Pages 2005
Photoregulation of DNA polymerase I (Klenow) with caged fluorescent oligodeoxynucleotides Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents Fulltext Access 4 Pages 2005
Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): A radiolabelled glycogen synthase kinase-3β specific inhibitor for PET studies Fulltext Access 4 Pages 2005
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome Fulltext Access 4 Pages 2005
Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals Fulltext Access 4 Pages 2005
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors Fulltext Access 4 Pages 2005
Structure–activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor Fulltext Access 4 Pages 2005
Self-complementary peptides for the formation of collagen-like triple helical supramolecules Fulltext Access 4 Pages 2005
Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes Fulltext Access 4 Pages 2005
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents Fulltext Access 4 Pages 2005
In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors Fulltext Access 4 Pages 2005
Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase Fulltext Access 4 Pages 2005
Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine Fulltext Access 4 Pages 2005
Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide–protein interactions Fulltext Access 4 Pages 2005
Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors Fulltext Access 4 Pages 2005
Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand Fulltext Access 4 Pages 2005
Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Fulltext Access 4 Pages 2005
Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents Fulltext Access 4 Pages 2005
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis Fulltext Access 4 Pages 2005
A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression Fulltext Access 4 Pages 2005
Reactions of α-hydroxyethyl radicals with flavonoids of various structures Fulltext Access 4 Pages 2005
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat–TAR interactions: Squaryldiamide as a new potential bioisostere of unsubstituted guanidine Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7 Fulltext Access 4 Pages 2005
Structure–activity relationships of Erwinia carotovora quorum sensing signaling molecules Fulltext Access 4 Pages 2005
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase Fulltext Access 4 Pages 2005
Design, synthesis and structure-activity relationship of a series of fragment analogues of antistasin (ATS) and ghilantens (GLS) Fulltext Access 4 Pages 2005
Calorimetric and computational study of enthalpy of formation of 3,6-dibutanoic-1,2,4,5-tetroxane Fulltext Access 4 Pages 2005
Isolation, structure elucidation, preparation, and biological properties of neolambertellin Fulltext Access 4 Pages 2005
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors Fulltext Access 4 Pages 2005
Camptothecin binds to a synthetic peptide identified by a T7 phage display screen Fulltext Access 4 Pages 2005
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 4 Pages 2005
Investigation of factor Xa inhibitors containing non-amidine S1 elements Fulltext Access 4 Pages 2005
A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II) Fulltext Access 4 Pages 2005
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases Fulltext Access 4 Pages 2005
Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors Fulltext Access 4 Pages 2005