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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

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Fulltext Access 5 Pages 2017
Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery
Fulltext Access 5 Pages 2017
Periodontal disease as a potential factor of migraine chronification
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Heterogeneity of hypoxia in solid tumours and mechanochemical reactions with oxygen nanobubbles
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Biodegradable microrobots for targeting cell delivery
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Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines
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Brain-derived neurotrophic factor mediates cognitive improvements following acute exercise
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Papillary carcinoma of the thyroid in patients with primary hyperparathyroidism: Is there a link?
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Association between oxidative status and the composition of intestinal microbiota along the gastrointestinal tract
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Dilated cardiomyopathy-induced disruption of basement membrane alters the lever systems acting on the heart
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Could mucin 16 and colony-stimulating factor 2-receptor beta possible graft versus host disease biomarkers? Medical hypotheses
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Intermittent hypoxia as a means to improve aerobic capacity in type 2 diabetes
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Magneto-electric nanocarriers for drug delivery: An overview
Fulltext Access 5 Pages 2017
Bottom-up gamma and stages of waking
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Evaluation of lidocaine loaded clay based dermal patch systems
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Purification of isopropyl fatty acids markedly changed the skin permeation of a model hydrophilic chemical
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Effects of nonsteroidal anti-inflammatory drugs on the renal excretion of indoxyl sulfate, a nephro-cardiovascular toxin, in rats
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What do people with hypertension use to reduce blood pressure in addition to conventional medication - Is this related to adherence?
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Mapping traditional and complementary medicine in Turkey
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Effects of auricular acupressure therapy for preventing constipation in leukemia patients undergoing chemotherapy: Protocol for a systematic review
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The effects of foot reflexology on anxiety and physiological parameters among candidates for bronchoscopy: A randomized controlled trial
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Stability studies on florfenicol using developed derivative spectrophotometric methods
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Empirical drug discovery: a view from the proteome
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The unique status of first-in-human studies: strengthening the social value requirement
Fulltext Access 5 Pages 2017
What if houses were powered by milk?
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Azobenzene-containing photoswitchable proteasome inhibitors with selective activity and cellular toxicity
Fulltext Access 5 Pages 2017
Artificial Intelligence Tools for Scaling Up of High Shear Wet Granulation Process
Fulltext Access 5 Pages 2017
Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization
Fulltext Access 5 Pages 2017
Combined proportional and additive residual error models in population pharmacokinetic modelling
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Improved predictions of nonlinear support vector regression and artificial neural network models via preprocessing of data with orthogonal projection to latent structures: A case study
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An Opinion on non-human primates testing in Europe
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European regulatory use and impact of subgroup evaluation in marketing authorisation applications
Fulltext Access 5 Pages 2017
Synthesis, characterization, photophysical properties and stability of bay-substituted tetrachloro-perylene diimide dianion salt by alkali treatment
Fulltext Access 5 Pages 2017
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs
Fulltext Access 5 Pages 2017
A comparative study of warheads for design of cysteine protease inhibitors
Fulltext Access 5 Pages 2017
Antibacterial activities of viriditoxin congeners and synthetic analogues against fish pathogens
Fulltext Access 5 Pages 2017
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design
Fulltext Access 5 Pages 2017
A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies
Fulltext Access 5 Pages 2017
Darstellung stabiler 1,2-acetoxonium-salze acetylierter hexosen und pentosen
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Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow
Fulltext Access 5 Pages 2017
A new dawn in cannabinoid neurobiology: The road from molecules to therapeutic discoveries
Fulltext Access 5 Pages 2017
Does complement Factor H-Related protein 5 Nephropathy (Troodos Nephropathy) protect from rickettsial infections?
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Hypothesis: A perfect day conveys internal time
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Hypocapnic hypothesis of Leigh disease
Fulltext Access 5 Pages 2017
Perfusion computed tomography imaging of abdominal aortic aneurysms may be of value for patient specific rupture risk estimation
Fulltext Access 5 Pages 2017
Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor
Fulltext Access 5 Pages 2017
High altitude and pre-eclampsia: Adaptation or protection
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Calcium-channel blockers as therapeutic agents for acquired sensorineural hearing loss
Fulltext Access 5 Pages 2017
Intra-spinal microstimulation may alleviate chronic pain after spinal cord injury
Fulltext Access 5 Pages 2017
Boron - A potential goiterogen?
Fulltext Access 5 Pages 2017
Acetanilide and bromoacetyl-lysine derivatives as activators for human histone deacetylase 8
Fulltext Access 5 Pages 2017
A four-blade light-driven plastic mill based on hydrazone liquid-crystal networks
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Competitive inclusion of molecular photo-switches in host cavities
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A trypsin-based bistable switch
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Nucleophilic disulfurating reagents for unsymmetrical disulfides construction via copper-catalyzed oxidative cross coupling
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Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling
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Synthesis and biological activity of salinomycin-hydroxamic acid conjugates
Fulltext Access 5 Pages 2017
Broad spectrum anti-infective properties of benzisothiazolones and the parallels in their anti-bacterial and anti-fungal effects
Fulltext Access 5 Pages 2017
Antitubulin effects of aminobenzothiophene-substituted triethylated chromones
Fulltext Access 5 Pages 2017
Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators
Fulltext Access 5 Pages 2017
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity
Fulltext Access 5 Pages 2017
Generation of a cysteine sulfinic acid analog for incorporation in peptides using solid phase peptide synthesis
Fulltext Access 5 Pages 2017
Potent and selective oxytocin receptor agonists without disulfide bridges
Fulltext Access 5 Pages 2017
Ester hydrolysis: Conditions for acid autocatalysis and a kinetic switch
Fulltext Access 5 Pages 2017
Structural insight into the active site of mushroom tyrosinase using phenylbenzoic acid derivatives
Fulltext Access 5 Pages 2017
Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening
Fulltext Access 5 Pages 2017
Chemical screening and development of novel gibberellin mimics
Fulltext Access 5 Pages 2017
Anti-influenza activity of diazaadamantanes combined with monoterpene moieties
Fulltext Access 5 Pages 2017
Synthesis of novel forskolin isoxazole derivatives with potent anti-cancer activity against breast cancer cell lines
Fulltext Access 5 Pages 2017
Original endomorphin-1 analogues exhibit good analgesic effects with minimal implications for human sperm motility
Fulltext Access 5 Pages 2017
Design and synthesis of new triazoles linked to xanthotoxin for potent and highly selective anti-gastric cancer agents
Fulltext Access 5 Pages 2017
Silver-catalyzed diastereo- and enantioselective Michael additions of 2-oxazoline- and 2-thiazoline-4-carboxylate to nitroalkenes
Fulltext Access 5 Pages 2017
Solvent free, fast and asymmetric Michael additions of ketones to nitroolefins using chiral pyrrolidine-pyridone conjugate bases as organocatalysts
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Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases
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Liposomal encapsulation masks genotoxicity of a chemotherapeutic agent in regulatory toxicology assessments
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Dihydropyridazine-appended dibenzosuberenones as a new class of fluorophores: Application to fluoride sensing
Fulltext Access 5 Pages 2017
meso-Tetraaryl-7,8-dihydroxydithiachlorins: first examples of heterochlorins
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Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones
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Synthesis of biaryl-linked cyclic peptoids
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Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling
Fulltext Access 5 Pages 2017
Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system
Fulltext Access 5 Pages 2017
Direct palladium-catalyzed allylic alkylations of alcohols with enamines: Synthesis of homoallyl ketones
Fulltext Access 5 Pages 2017
Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides
Fulltext Access 5 Pages 2017
Mercuration of calix[4]arenes immobilized in the 1,2- and 1,3-alternate conformations
Fulltext Access 5 Pages 2017
Tandem and chemoselective synthesis of benzil derivatives from styrene and arene diazonium salts
Fulltext Access 5 Pages 2017
Biomimetic total synthesis and structure confirmation of myrtucommulone K
Fulltext Access 5 Pages 2017
Synthesis of allyl sulfones from potassium allyltrifluoroborates
Fulltext Access 5 Pages 2017
Synthesis and structural characterization of a highly substituted triazine ring comprising a sterically flexible methylene linker and coordinating substituents
Fulltext Access 5 Pages 2017
Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation
Fulltext Access 5 Pages 2017
An expeditious synthetic protocol for chlorination of imidazole N-oxide: Synthesis of 2-chloroimidazoles
Fulltext Access 5 Pages 2017
Piperidine promoted aldol reaction of alkynyl aldehydes and ethyl diazoacetate
Fulltext Access 5 Pages 2017
Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine
Fulltext Access 5 Pages 2017
2,2,4,4-Tetrathio substituted 1,3-dithietanes
Fulltext Access 5 Pages 2017
A coumarin-based fluorescent and colorimetric chemosensor for rapid detection of fluoride ion
Fulltext Access 5 Pages 2017
Palladium-catalyzed direct arylation of maleimides: A simple route to bisaryl-substituted maleimides
Fulltext Access 5 Pages 2017
Synthesis of spiroisoxazolidinyl-benzoisothiazolines by 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes with nitrones
Fulltext Access 5 Pages 2017
Double Michael addition of nitromethane to divinyl ketones: A remarkably positive effect of additive
Fulltext Access 5 Pages 2017
Copper-catalyzed reductive borylations on water
Fulltext Access 5 Pages 2017
Synthesis of 2-deoxy ribose related disaccharide nucleoside and its phosphoramidite
Fulltext Access 5 Pages 2017
Theoretical investigations on the conversions of cyclic polysulfides to acyclic polysulfide diradicals and subsequent reactions of biological interest
Fulltext Access 5 Pages 2017
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